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  • Author(s):
    Colin Flinders, Shannon M. Mumenthaler, Amanda B. Hummon, Xin Liu
    Abstract:

    Patient-derived colorectal tumor organoids (CTOs) closely recapitulate the complex morphological, phenotypic, and genetic features observed in in vivo tumors. Therefore, evaluation of drug distribution and metabolism in this model system can provide valuable information to predict the clinical outcome of a therapeutic response in individual patients. In this report, we applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to examine the spatial distribution…

    Date Published:
    2018-03
  • Author(s):
    Karen A. Bailey, Yuliya Klymenko, Peter E. Feist, Amanda B. Hummon, M. Sharon Stack, Zachary D. Schultz
    Abstract:

    Ovarian cancer (OvCa) cells are reported to undergo biochemical changes at the cell surface in response to treatment with lysophosphatidic acid (LPA). Here we use scanning electron microscopy (SEM) and multiplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe morphological changes that result from LPA treatment. SEM images show distinct shedding of microvilli-like features upon treatment with LPA. Analysis of multiplex CARS images can distinguish be…

    Date Published:
    2017
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 9580756 B2
    Description:

    Compositions/methods for employing fresh-frozen or FFPE colon cancer tissue in left side colon cancer (LCC) and right-side colon cancer (RCC) disease patients for risk of relapse assessment/stratification is provided (3 strata and a 4 strata methodology). An RCC gene panel of 4 genes (FAM69A, CDX2, FAM84A, ITGA3), and 9 genes (FAM69A, CDX2, ITGA3, FAM84A, ITPRIP, RAB3B, SMAD3, PCSK5, MMP28), is provided. An LCC gene panel of 4 genes (NOX4, WNT5A, MMP3, IBSP), and a 9 genes (MMP3, WINT5A, NOX4…

    Date Issued:
    2017-02-28
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 9464328 B2
    Description:

    Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression v…

    Date Issued:
    2016-10-11
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 10,087,489 B2
    Description:

    Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression v…

    Date Issued:
    2018-10-02
    Resource Type
    Patent