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- Inventor(s):
- Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan J. Alves, Jonathan D. Ashley, Michael W. Handlogten
- Patent Number:
- US 9598460 B2
- Description:
Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in s…
- Date Issued:
- 2017-03-21
- Record Visibility:
- Public
- Title
- Antibody purification via affinity chromatography
- Description
- Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid.
- Creator
- Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan J. Alves, Jonathan D. Ashley, Michael W. Handlogten
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
- Patent Number:
- US 9872870 B2
- Description:
Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cel…
- Date Issued:
- 2018-01-23
- Record Visibility:
- Public
- Title
- Multifunctional micellar nanoparticle-based drug and targeting agent system
- Description
- Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.
- Creator
- Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent