Articles & Publications
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1
Article
- Author(s):
- Eldin Jasarević, Jie Ning, Ashley N Daniel, Rachel A Menegaz, Jeffrey J Johnson, M Sharon Stack, Matthew J Ravosa
- Abstract:
In contrast to experimental evidence regarding the postorbital bar, postorbital septum, and browridge, there is exceedingly little evidence regarding the load-bearing nature of soft-tissue structures of the mammalian circumorbital region. This hinders our understanding of pronounced transformations during primate origins, in which euprimates evolved a postorbital bar from an ancestor with the primitive mammalian condition where only soft tissues spanned the lateral orbital margin between fron…
- Date Published:
- 2010-04-01
- Record Visibility:
- Public
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- Author(s):
- Matthew J Ravosa, Elisabeth K López, Rachel A Menegaz, Stuart R Stock, M Sharon Stack, Mark W Hamrick
- Abstract:
Knockout mice lacking myostatin (Mstn), a negative regulator of the growth of skeletal muscle, develop significant increases in the relative mass of masticatory muscles as well as the ability to generate higher maximal muscle forces. Wild-type and Mstn-deficient mice were compared to investigate the postnatal influence of elevated masticatory loads due to increased jaw-adductor and bite forces on the biomineralization of mandibular articular and cortical bone, the internal structure of the ja…
- Date Published:
- 2008-09-01
- Record Visibility:
- Public
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- Author(s):
- Michelle M Woo, Clara M Salamanca, Jaime Symowicz, M Sharon Stack, Dianne M Miller, Peter C Leung, C Blake Gilks, Nelly Auersperg
- Abstract:
Objective: Serous borderline ovarian tumors (SBOT) are slow growing, noninvasive ovarian epithelial neoplasms, which tend to recur as low-grade invasive carcinomas (LGC) with a much worse prognosis. We investigated the molecular basis of this progression. Methods: We established cultures of three SBOTs and one LGC from tumor biopsies, and inactivated p53, Rb and PP2A in the cells with SV40 large T (LT) and small T (ST) antigen. They were examined for cadherins by immunofluorescence and immun…
- Date Published:
- 2008-10-01
- Record Visibility:
- Public
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- Author(s):
- Zonggao Shi, Jeffrey J Johnson, Rong Jiang, Yueying Liu, M Sharon Stack
- Abstract:
With the aim to identify microRNAs that may contribute to oral squamous cell carcinoma (OSCC) progression, we compared the microRNA expression profiles of two related cell lines that form tumors with differential aggressiveness. A panel of 28 microRNAs was found to be more than 1.5-fold altered, among which miR-146a was the most significantly changed (-4.6-fold). Loss of miR-146a expression was validated in human high-grade tumors, while normal oral mucosa retained expression, using fluoresce…
- Date Published:
- 2015-09
- Record Visibility:
- Public
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- Author(s):
- Zonggao Shi, Jeff J Johnson, M Sharon Stack
- Abstract:
The technique of nucleic acid in situ hybridization is an effective method for identifying the existence and abundance of nucleic acids in tissue sections or cytological preparations. Such a method has the advantage of keeping morphological relationships intact while identifying changes at the molecular level. As a noncoding regulatory RNA, microRNA has been found to intricately control many physiological and pathological conditions. We provide here a representative fluorescence in situ hybri…
- Date Published:
- 2013-07-02
- Record Visibility:
- Public
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- Author(s):
- Jochen H Lorch, Jodi Klessner, J Ken Park, Spiro Getsios, Yvonne L Wu, M Sharon Stack, Kathleen J Green
- Abstract:
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions, particularly in tumors that overexpress this tyrosine kinase. Here the EGFR tyrosine kinase inhibitor PKI166 and EGFR blocking antibody C225, both of which are used clinically to treat head and neck cancers, were used to determine the effects of EGFR inhibition on intercellular junction assembly and adhesion in oral squamous cell carcinoma cells. EGFR inhibition res…
- Date Published:
- 2004-08-27
- Record Visibility:
- Public
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- Author(s):
- Reema Zeineldin, Martina Rosenberg, Dominic Ortega, Christian Buhr, Miquella G Chavez, M Sharon Stack, Donna F Kusewitt, Laurie G Hudson
- Abstract:
Overexpression of the epidermal growth factor (EGF) receptor occurs frequently in ovarian cancer and is associated with poor patient prognosis. A constitutively active mutant EGF receptor termed variant III (EGFRvIII) has been detected at a high frequency in many human tumors, including those of the ovary. To identify the consequences of EGFRvIII expression in ovarian tumor cells, we introduced EGFRvIII into the epithelial ovarian cancer cell line (OVCA 433). The EGFRvIII-transfected cells di…
- Date Published:
- 2006-11-01
- Record Visibility:
- Public
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- Author(s):
- Thuy-Vy Do, Jay C Symowicz, David M Berman, Lance A Liotta, Emanuel F Petricoin 3rd, M Sharon Stack, David A Fishman
- Abstract:
Epithelial ovarian cancer (EOC) is asymptomatic at early stages and is often diagnosed late when tumor cells are highly metastatic. Lysophosphatidic acid (LPA) has been implicated in ovarian oncogenesis as levels of this lipid are elevated in patient ascites and plasma. Because the underlying mechanism governing LPA regulation of matrix metalloproteinase-2 (MMP-2) activation remains undefined, we investigated the relationship between LPA-induced changes in actin microfilament organization and…
- Date Published:
- 2007-02-01
- Record Visibility:
- Public
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- Author(s):
- Eric M Tam, Charlotte J Morrison, Yi I Wu, M Sharon Stack, Christopher M Overall
- Abstract:
By proteolytic modification of low abundant signaling proteins and membrane receptors, proteases exert potent posttranslational control over cell behavior at the postsecretion level. Hence, substrate discovery is indispensable for understanding the biological role of proteases in vivo. Indeed, matrix metalloproteinases (MMPs), long associated with extracellular matrix degradation, are increasingly recognized as important processing enzymes of bioactive molecules. MS is now the primary proteom…
- Date Published:
- 2004-05-04
- Record Visibility:
- Public
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- Author(s):
- Subhendu Mukhopadgyay, Hidayatullah G Munshi, Suman Kambhampati, Antonella Sassano, Leonidas C Platanias, M Sharon Stack
- Abstract:
Matrix metalloproteinases (MMPs) play an important role in the invasive behavior of a number of cancers including oral squamous cell cancer (OSCC), and increased expression of MMP-9 is correlated with invasive and metastatic OSCC. Because calcium is an important regulator of keratinocyte function, the effect of modulating extracellular calcium on MMP-9 expression in OSCC cell lines was evaluated. Increasing extracellular calcium induced a dose-dependent increase in MMP-9 expression in immorta…
- Date Published:
- 2004-08-06
- Record Visibility:
- Public
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11
Article
- Author(s):
- Yueying Liu, Rebecca Burkhalter, Jaime Symowicz, Kim Chaffin, Shawn Ellerbroek, M Sharon Stack
- Abstract:
Ovarian cancer metastasizes via exfoliation of free-floating cells and multicellular aggregates from the primary tumor to the peritoneal cavity. A key event in EOC metastasis is disruption of cell-cell contacts via modulation of intercellular junctional components including cadherins. Ascites is rich in lysophosphatidic acid (LPA), a bioactive lipid that may promote early events in ovarian cancer dissemination. The objective of this paper was to assess the effect of LPA on E-cadherin junction…
- Date Published:
- 2012
- Record Visibility:
- Public
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- Author(s):
- Kyle A Lewellen, Matthew N Metzinger, Yueying Liu, M Sharon Stack
- Abstract:
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy in the United States. Mortality is due to diagnosis of 75% of women with late stage disease, when metastasis is already present. EOC is characterized by diffuse and widely disseminated intra-peritoneal metastasis. Cells shed from the primary tumor anchor in the mesothelium that lines the peritoneal cavity as well as in the omentum, resulting in multi-focal metastasis, often in the presence of peritoneal …
- Date Published:
- 2016-07-18
- Record Visibility:
- Public