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  • Author(s):
    Marie Lynn Miranda, Rashida Callender, Joally M. Canales, Elena Craft, Katherine B. Ensor, Max Grossman, Loren Hopkins, Jocelyn Johnston, Umair Shah, Joshua Tootoo
    Abstract:

    BACKGROUND: Making landfall in Rockport, Texas in August 2017, Hurricane Harvey resulted in unprecedented flooding, displacing tens of thousands of people, and creating environmental hazards and exposures for many more.

    OBJECTIVE: We describe a collaborative project to establish the Texas Flood Registry to track the health and housing impacts of major flooding events.

    METHODS: Those who enroll in the registry answer retrospective questions regarding the impact of storms on their health and …

    Date Published:
    2021-06
    Record Visibility:
    Public
  • Author(s):
    Mercedes A.Bravo, Marie Lynn Miranda
    Abstract:

    Abstract Background Persistent disparities in academic performance may result from a confluence of adverse exposures accruing disproportionately to specific subpopulations.

    Objective Our overarching objective was to investigate how multiple exposures experienced over time affect early childhood educational outcomes. We were specifically interested in whether there were: racial/ethnic disparities in prevalence of adverse exposures; racial/ethnic disparities in associations observed between ad…

    Date Published:
    2021-07
    Record Visibility:
    Public
  • Author(s):
    David C. Bailey, Michael D. Seamon, Marie Lynn Miranda
    Abstract:

    Summary What is already known about this topic?

    Although various implementation strategies for SARS-CoV-2 testing on college and university campuses have been described, little has been published regarding successful responses to COVID-19 outbreaks on campus.

    What is added by this report?

    In response to a COVID-19 outbreak on a university campus in August 2020, rapid implementation of multiple measures, including aggressive testing, tracing, and isolation; enhanced data systems; and commun…

    Date Published:
    2021-01-29
    Record Visibility:
    Public
  • Author(s):
    Veronica J. Berrocal, Marie Lynn Miranda, Alan E. Gelfand, Sourabh Bhattacharya
    Abstract:

    A common data analysis setting consists of a collection of datasets of varying sizes that are all relevant to a particular scientific question, but which include different subsets of the relevant variables, presumably with some overlap. Here, we demonstrate that synthesizing cross-classified categorical datasets drawn from an incompletely cross-classified common population, where many of the sets are incomplete (i.e., one or more of the classification variables is unobserved), but at least on…

    Date Published:
    2013-11-01
    Record Visibility:
    Public
  • Author(s):
    Dohyeong Kim, Zachary Brown, Richard Anderson, Clifford Mutero, Marie Lynn Miranda, Jonathan Wiener, Randall Kramer
    Abstract:

    Decision analysis tools and mathematical modeling are increasingly emphasized in malaria control programs worldwide to improve resource allocation and address ongoing challenges with sustainability. However, such tools require substantial scientific evidence, which is costly to acquire. The value of information (VOI) has been proposed as a metric for gauging the value of reduced model uncertainty. We apply this concept to an evidenced-based Malaria Decision Analysis Support Tool (MDAST) desig…

    Date Published:
    2016-03-23
    Record Visibility:
    Public
  • Author(s):
    Harrison Quick, Joshua Tootoo, Ruiyang Li, Adam S. Vaughan, Linda Schieb, Michele Casper, Marie Lynn Miranda
    Abstract:

    Accurate and precise estimates of local-level epidemiologic measures are critical to informing policy and program decisions, but they often require advanced statistical knowledge, programming/coding skills, and extensive computing power. In response, we developed the Rate Stabilizing Tool (RST), an ArcGIS-based tool that enables users to input their own record-level data to generate more reliable age-standardized measures of chronic disease (eg, prevalence rates, mortality rates) or other pop…

    Date Published:
    2019-03-28
    Record Visibility:
    Public
  • Author(s):
    Sayanti Bhattacharya, Ashley A Dunham, Melissa A Cornish, Victoria A Christian, Geoffrey S Ginsburg, Jessica D Tenenbaum, Meredith L Nahm, Marie Lynn Miranda, Robert M Califf, Rowena J Dolor, L Kristin Newby
    Abstract:

    Current understanding of chronic diseases is based on crude clinical characterization, imaging studies, and laboratory testing that has evolved over decades. The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study is a multi-tiered, longitudinal study designed to enable classification of chronic diseases using clinically annotated biospecimen collections, -omic technologies, electronic health records, and standard epidemiological methods. We expect tha…

    Date Published:
    2012-10-10
    Record Visibility:
    Public
  • Author(s):
    Mercedes A. Bravo, Rebecca Anthopolos, Michelle L. Bell, Marie Lynn Miranda
    Abstract:

    Background - Researchers and policymakers are increasingly focused on combined exposures to social and environmental stressors, especially given how often these stressors tend to co-locate. Such exposures are equally relevant in urban and rural areas and may accrue disproportionately to particular communities or specific subpopulations.

    Objectives-To estimate relationships between racial isolation (RI), a measure of the extent to which minority racial/ethnic group members are exposed to only…

    Date Published:
    2016-07-15
    Record Visibility:
    Public
  • Author(s):
    Julie Strominger, Rebecca Anthopolos, Marie Lynn Miranda
    Abstract:

    Background - Research surrounding the built environment (BE) and health has resulted in inconsistent findings. Experts have identified the need to examine methodological choices, such as development and testing of BE indices at varying spatial scales. We sought to examine the impact of construction method and spatial scale on seven measures of the BE using data collected at two time points. Methods - The Children’s Environmental Health Initiative conducted parcel-level assessments of 57 BE v…

    Date Published:
    2016-04-28
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    Public
  • Author(s):
    Christopher Leonetti, Craig M. Butt, Kate Hoffman, Marie Lynn Miranda, Heather M. Stapleton
    Abstract:

    Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a su…

    Date Published:
    2015-12-14
    Record Visibility:
    Public
  • Author(s):
    Sharon Edwards, Pamela Maxson, Nicole Sandberg, Marie Lynn Miranda
    Abstract:

    Children born with low birth weight, preterm, or with fetal growth restriction may suffer from significant short and long term morbidity and mortality, making adverse pregnancy outcomes a major public health concern with significant health, social, and economic consequences for families, communities, and the nation. Despite aggressive public heath campaigns, racial and geographic disparities in pregnancy outcomes persist. Disproportionate exposure to environmental hazards may partially accoun…

    Date Published:
    2015-12-31
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    Public
  • Author(s):
    Chad A.Grotegut, Emily Ngan, Melanie E.Garrett, Marie Lynn Miranda, Allison E.Ashley-Koch, Geeta K.Swamy
    Abstract:

    Background Oxytocin is a potent uterotonic agent that is widely used for induction and augmentation of labor. Oxytocin has a narrow therapeutic index and the optimal dosing for any individual woman varies widely.

    Objective The objective of this study was to determine whether genetic variation in the oxytocin receptor (OXTR) or in the gene encoding G protein–coupled receptor kinase 6 (GRK6), which regulates desensitization of the oxytocin receptor, could explain variation in oxytocin dosing a…

    Date Published:
    2017-09-01
    Record Visibility:
    Public