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  • Inventor(s):
    Marvin J. Miller, Cheng Ji, Patricia A. Miller
    Patent Number:
    US 9302012 B2
    Description:

    An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-cat…

    Date Issued:
    2016-04-05
    Record Visibility:
    Public
    Resource Type
    Patent