Notre Dame Patents

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Description

This collection brings together all of the patents assigned to the University of Notre Dame from 1952 to 2020, plus other selected patents prior to 1952. Each record includes a full-text searchable and accessible PDF document for the corresponding invention. The record also includes the present-day academic department with which the inventor was or would have been associated.

Why patents? According to the University’s IDEA Center, “Part of the University’s public service mission is to ensure that the results of its research are made available for public use and benefit. This is accomplished in many ways: through educating students, publishing results of research, and ensuring that inventions are developed into useful products and services for the benefit of the public.”

“Today, our research universities play an even more vital role in creating a better future—not only by educating close to 600,000 graduate students in science and engineering every year, but also, and critically, by performing more than 15% of U.S. R&D in 2011—and according to 2012 NSF data, accounted for the majority (53%) of national basic research. This research, some basic, some applied or ‘translational’ creates new technologies, new products and services, medicines, diagnostics — the list is long and impressive — but also, this research gives rise to entire new industries.” (David Winwood, “The Importance of Patents and Academic Technology Transfer,” March 26, 2015)

The collection also includes the most famous patent associated with Notre Dame, U.S. patent 1,811,959 from 1931, “Vinyl derivatives of acetylene and method of preparing the same” — in other words, synthetic rubber. Invented by Rev. Fr. Julius Nieuwland, CSC, and assigned to DuPont, this patent did, in fact, give rise to entire new industries. More about this invention may be found at the National Inventors Hall of Fame.

These patents are one more example of the University fulfilling Rev. Fr. Sorin’s vision of becoming a “powerful force for good.”

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  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4595532 B2
    Description:

    N-Mono or N-disubstituted methyl-2-azetidinones are provided via cyclization of .beta.-hydroxy or .beta.-halo substituted acid sec-amides wherein the amide nitrogen is substituted with a mono- or di-substituted methyl group having activating substituents. Cyclization of .beta.-hydroxy acid amides is mediated by triphenylphosphine-dialkylazodicarboxylate while cyclization of .beta.-halo acid amides is mediated by strong bases e.g. lithium dialkylamides. E.g. Diethyl amino-protected L-serylamin…

    Date Issued:
    1986-06-17
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Yanping Xu
    Patent Number:
    US 6310058 B2
    Description:

    Compounds represented by the formula [1] ##STR1## R.sub.1 is H or a substituent; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is siderophore group e.g. CH.sub.3 –(CH.sub.2).sub.n –C(O)–N(OH)–(CH.sub.2).sub.m – with n=10-22, m=2-6; X is O, S, or NH; X.sub.1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX.sub.1 is HO– or H.sub….

    Date Issued:
    2001-10-30
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 5266468 B2
    Description:

    .beta.-Hydroxy-.alpha.-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methylester is condensed with glycine in the process to provide L-erythro .alpha.-amino hydroxy adipic acid mono methyl ester.

    Date Issued:
    1993-11-30
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4675399 B2
    Description:

    Process for N-acyloxy or sulfooxy 2-azetidinones comprising O-acylation of a .beta.-hydroxy or .beta.-halo hydroxamic acid, and cyclizing the O-acylhydroxamate with TPP-CCl.sub.4 -TEA or with TPP-dialkylazodicarboxylate to the N-acyloxy-2-azetidinone. Solvolysis of the acyl group provides an N-hydroxy-2-azetidinone. e.g., N-Cbz-L-serine is converted to the O-acetyl hydroxamate, cyclized and solvolyzed to N-hydroxy-3-(Cbz-amino)-2-azetidinone. The N-hydroxy-2-azetidinones are useful intermedia…

    Date Issued:
    1987-06-23
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4845229 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1989-07-04
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Jingdan Hu
    Patent Number:
    US 6403623 B2
    Description:

    Method for treating tuberculosis with 2-(2-substituted-phenyl)-2-oxazolines and related 5-membered heterocycles represented by the formula ##STR1## Y.sub.1 is e.g. an ester or amide forming group, and X is O, S, or NH; and pharmaceutically acceptable formulations useful therein are provided. A preferred method comprises administering (S)-benzyl2-[2-(benzyloxy)phenyl]-2-oxazoline-4-carboxylate in a suitable formulation. The compounds of the above formula are prepared by known methods, e.g. the…

    Date Issued:
    2002-06-11
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Min Teng, Marvin J. Miller
    Patent Number:
    US 5750681 B2
    Description:

    Bicyclic .beta.-lactams comprising a 5- or 6-membered lactone or lactam ring are obtained in a process comprising a base induced intramolecular cyclization of a 4-substututed .beta.-lactam having a leaving group in the 1-position. An intramolecular nucleophile transfer reaction is proposed as the operative mechanism and the bicyclic .beta.-lactams are obtained in the required stereochemical form for biological activity. The compounds provided are useful intermediates for the preparation of an…

    Date Issued:
    1998-05-12
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
    Patent Number:
    US 9309238 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.

    Date Issued:
    2016-04-12
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Rohit Tiwari
    Patent Number:
    US 9708339 B2
    Description:

    A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein E includes an electrophilic site, and wherein R.sup.1-R.sup.4 and n are defined herein. Compositions and methods including the compound are also provided.

    Date Issued:
    2017-07-18
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Julia M. Dolence, Manuka Ghosh
    Patent Number:
    US 5783689 B2
    Description:

    5’-O-Acyl-5-fluorouridines and 5’-O-acyl-5-sluorocytidines are prepared by the direct acylation of the 5’-hydroxyl group with amino acids under Mitsunobu conditions and the amino acyl derivatives are coupled with other amino acids or peptides to provide antibacterial and antifungal derivatives of the nucleosides. For example, 5-fluorouridine is acylated at the 5’-hydroxyl group with an amino protected L-valine and the acylation product is deprotected to provide 5’-O-(L-val…

    Date Issued:
    1998-07-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4745201 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenum and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1988-05-17
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4751296 B2
    Description:

    A process for 4-halomethylazetidin-2-ones is provided which comprises mixing in an inert solvent a positive halogen reagent in the presence of a weak base with a .beta.,.gamma.-unsaturated O-acylhydroxamate of the formula ##STR1## wherein R is protected amino, lower alkyl or phenyl substituted lower alkyl, R.sub.2 is a substituent such as lower alkyl which may be substituted by formyl, hydroxy, halogen, etc., and R.sub.1 is alkoxy, benzyloxy, etc. When R is a protected amino group, the proces…

    Date Issued:
    1988-06-14
    Record Visibility:
    Public
    Resource Type
    Patent