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  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
    Patent Number:
    US 9045442 B2
    Description:

    Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.

    Date Issued:
    2015-06-02
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 9321754 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2016-04-26
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 8937151 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2015-01-20
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery
    Patent Number:
    US 9604957 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

    Date Issued:
    2017-03-28
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Renee Bouley
    Patent Number:
    US 9,776,975 B2
    Description:

    A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding…

    Date Issued:
    2017-10-03
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 9867805 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2018-01-16
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery
    Patent Number:
    US 9951035 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

    Date Issued:
    2018-04-24
    Resource Type
    Patent