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- Inventor(s):
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Patent Number:
- US 9186402 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2015-11-17
- Record Visibility:
- Public
- Title
- Method for preparing largazole analogs and uses thereof
- Description
- Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Creator
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- 2016-05-10
- Record Visibility:
- Public
- Title
- Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick type C disease
- Description
- Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Creator
- Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent