Search criteria:
List of files deposited in CurateND that match your search criteria
-
- Inventor(s):
- Olaf G. Wiest, Paul Helquist, Frederick R. Maxfield
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- May 10, 2016
- Record Visibility:
- Public
- Title
- Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick type C disease
- Description
- Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Creator
- Olaf G. Wiest, Paul Helquist, Frederick R. Maxfield
- Publisher
- United States Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Patent Number:
- US 9186402 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2015-11-17
- Record Visibility:
- Public
- Title
- Method for preparing largazole analogs and uses thereof
- Description
- Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Creator
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- 2016-05-10
- Record Visibility:
- Public
- Title
- Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick type C disease
- Description
- Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Creator
- Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
- Patent Number:
- US 10538534 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer’s Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2020-01-21
- Record Visibility:
- Public
- Title
- Synthesis and utility of new capgroup largazole analogs
- Description
- Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Creator
- Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
- Language
- English
- Rights
- https://creativecommons.org/licenses/by-nc-sa/3.0/
- Resource Type
- Patent
-
- Inventor(s):
- Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
- Patent Number:
- US 10676504 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2020-06-09
- Record Visibility:
- Public
- Title
- Method for preparing largazole analogs and uses thereof
- Description
- Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Creator
- Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
- Language
- English
- Rights
- https://creativecommons.org/licenses/by-nc-sa/3.0/
- Resource Type
- Patent
-
- Inventor(s):
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Patent Number:
- US 8513290 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2013-08-20
- Record Visibility:
- Public
- Title
- Method for preparing largazole analogs and uses thereof
- Description
- Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Creator
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Publisher
- United States Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent