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  • Author(s):
    Sage J. B. Dunham, Joseph F. Ellis, Nameera F. Baig, Nydia Morales-Soto, Tianyuan Cao, Joshua D. Shrout, Paul W. Bohn, Jonathan V. Sweedler
    Abstract:

    After several decades of widespread use for mapping elemental ions and small molecular fragments in surface science, secondary ion mass spectrometry (SIMS) has emerged as a powerful analytical tool for molecular imaging in biology. Biomolecular SIMS imaging has primarily been used as a qualitative technique; although the distribution of a single analyte can be accurately determined, it is difficult to map the absolute quantity of a compound or even to compare the relative abundance of one mol…

    Date Published:
    2018
  • Author(s):
    Kaiyu Fu, Donghoon Han, Chaoxiong Ma, Paul W. Bohn
    Abstract:

    Surface charge characteristics and the electrical double layer (EDL) effect govern the transport of ions into and out of nanopores, producing a permselective concentration polarization, which dominates the electrochemical response of nanoelectrodes in solutions of low ionic strength. In this study, highly ordered, zero-dimensional nanopore electrode arrays (NEAs), with each nanopore presenting a pair of recessed electrodes, were fabricated to couple EDL effects with redox cycling, thereby ach…

    Date Published:
    2017
  • Author(s):
    Kaiyu Fu, Paul W. Bohn
    Abstract:

    The ability to design, fabricate, and manipulate materials at the nanoscale is fundamental to the quest to develop technologies to assemble nanometer-scale pieces into larger-scale components and materials, thereby transferring unique nanometer-scale properties to macroscopic objects. In this work, we describe a new approach to the fabrication of highly ordered, ultrahigh density nanochannel arrays that employs nanosphere lithography to template the graphoepitaxy of polystyrene–polydimethylsi…

    Date Published:
    2017
  • Author(s):
    Sneha Polisetti, Nameera F. Baig, Nydia Morales-Soto, Joshua D. Shrout, Paul W. Bohn
    Abstract:

    Surface enhanced Raman spectroscopy (SERS) imaging was used in conjunction with principal component analysis (PCA) for the in situ spatiotemporal mapping of the virulence factor pyocyanin in communities of the pathogenic bacterium Pseudomonas aeruginosa. The combination of SERS imaging and PCA analysis provides a robust method for the characterization of heterogeneous biological systems while circumventing issues associated with interference from sample autofluorescence and low reproducibilit…

    Date Published:
    2016