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  • Author(s):
    Jeshina Janardhanan, Renee Bouley, Sisth Martinez-Caballero, Zhihong Peng, Mayte Batuecas-Mordillo, Jayda E. Meisel, Derong Ding, Valerie Schroder, William Wolter, Juan Hermoso, Shahriar Mobashery, Mayland Chang
    Abstract:

    The quinazolinones are a new class of antibacterials with in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA). The quinazolinones target cell wall biosynthesis and have a unique mechanism of action by binding to the allosteric site of penicillin-binding protein 2a (PBP 2a). We investigated the potential for synergism of a lead quinazolinone with several antibiotics of different classes using checkerboard and time-kill assays. The quinazolinone synergized with β-lactam …

    Date Published:
    2019-03
    Record Visibility:
    Public
  • Author(s):
    Trung T. Nguyen, Derong Ding, William R. Wolter, Matthew M. Champion, Dusan Hesek, Mijoon Lee, Rocio L. Pérez, Valerie A. Schroeder, Mark A. Suckow, Shahriar Mobashery, Mayland Chang
    Abstract:

    Chronic wounds are a complication of diabetes. Treatment for diabetic foot ulcers is complex with little clinical recourse, resulting in 108,000 lower-limb amputations annually in the United States alone. Matrix metalloproteinases (MMPs) play important roles in the pathology and in the repair of chronic wounds. We previously identified active MMP-8 and MMP-9 in wounds of diabetic mice and determined that MMP-8 accelerates wound repair, while MMP-9 is the culprit for the diabetic wound being r…

    Date Published:
    2018
    Record Visibility:
    Public