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  • Author(s):
    Trung T. Nguyen, Jeffrey Jones, Walter Wolter, Rocio Perez, Valerie Schroeder, Matthew Champion, Dusan Hesek, Mijoon Lee, Mark Suckow, Shahriar Mobashery, Mayland Chang
    Abstract:

    Diabetic foot ulcers are characterized by hypoxia. For many patients, hyperbaric oxygen (HBO) therapy is the last recourse for saving the limb from amputation, for which the molecular basis is not understood. We previously identified the active form of matrix metalloproteinase-9 (MMP-9) as responsible for diabetic foot ulcer’s recalcitrance to healing. Transcription of mmp-9 to the inactive zymogen is upregulated during hypoxia. Activation of the zymogen is promoted by proteases and react…

    Record Visibility:
    Public
  • Author(s):
    Trung T. Nguyen, Derong Ding, William R. Wolter, Matthew M. Champion, Dusan Hesek, Mijoon Lee, Rocio L. Pérez, Valerie A. Schroeder, Mark A. Suckow, Shahriar Mobashery, Mayland Chang
    Abstract:

    Chronic wounds are a complication of diabetes. Treatment for diabetic foot ulcers is complex with little clinical recourse, resulting in 108,000 lower-limb amputations annually in the United States alone. Matrix metalloproteinases (MMPs) play important roles in the pathology and in the repair of chronic wounds. We previously identified active MMP-8 and MMP-9 in wounds of diabetic mice and determined that MMP-8 accelerates wound repair, while MMP-9 is the culprit for the diabetic wound being r…

    Date Published:
    2018
    Record Visibility:
    Public
  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Record Visibility:
    Public
    Resource Type
    Patent