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  • Author(s):
    Chinedu Madukoma, Shusuke Tomoshige, Choonkeun Kim, Elan Lastochkin, William C. Boggess, Jed Fisher, Joshua Shrout, Shahriar Mobashery

    The interplay between the activities of lytic transglycosylases (LTs) and penicillin-binding proteins (PBPs) is critical for the health of the bacterial cell wall. Bulgecin A (a natural-product inhibitor of LTs) potentiates the activity of β-lactam antibiotics (inhibitors of PBPs), underscoring this intimate mechanistic interdependence. Bulgecin A in the presence of an appropriate β-lactam causes bulge deformation due to the formation of aberrant peptidoglycan at the division site of the bact…

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