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  • Author(s):
    Trung T. Nguyen, Jeffrey Jones, Walter Wolter, Rocio Perez, Valerie Schroeder, Matthew Champion, Dusan Hesek, Mijoon Lee, Mark Suckow, Shahriar Mobashery, Mayland Chang
    Abstract:

    Diabetic foot ulcers are characterized by hypoxia. For many patients, hyperbaric oxygen (HBO) therapy is the last recourse for saving the limb from amputation, for which the molecular basis is not understood. We previously identified the active form of matrix metalloproteinase-9 (MMP-9) as responsible for diabetic foot ulcer’s recalcitrance to healing. Transcription of mmp-9 to the inactive zymogen is upregulated during hypoxia. Activation of the zymogen is promoted by proteases and react…

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