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- Inventor(s):
- Siyuan Zhang, Jeremiah Zartman, David Hoelzle, Cody Narciso
- Patent Number:
- US 9975121 B2
- Description:
A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon app…
- Date Issued:
- 2018-05-22
- Record Visibility:
- Public
- Title
- Microfluidic devices, systems, and methods for evaluating tissue samples
- Description
- A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber.
- Creator
- Siyuan Zhang, Jeremiah Zartman, David Hoelzle, Cody Narciso
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Jeremiah Zartman, David Hoelzle, Cody Narciso, Siyuan Zhang, Wendy Alvarez Barrios, Victoria Zellmer
- Patent Number:
- US 10168259 B2
- Description:
One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel. The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet channel can be fluid communication with the tissue chamber. The liquid outlet channel can be in fluid communication with the tissue chamber. The tissue chamber can be sized and dimensioned …
- Date Issued:
- 2019-01-01
- Record Visibility:
- Public
- Title
- Microfluidic devices, systems, and methods for imaging tissue samples
- Description
- One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel. The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet channel can be fluid communication with the tissue chamber. The liquid outlet channel can be in fluid communication with the tissue chamber. The tissue chamber can be sized and dimensioned to completely immobilize the tissue sample during imaging.
- Creator
- Jeremiah Zartman, David Hoelzle, Cody Narciso, Siyuan Zhang, Wendy Alvarez Barrios, Victoria Zellmer
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent