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  • Author(s):
    Lisa Irimata, Tracy Vargo-Gogola, Ryan Roeder
    Abstract:

    A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands and a polyethylene glycol (PEG) spacer on targeted delivery of gold nanoparticles (Au NPs) for contrast-enhanced radiographic detection. The addition of BP ligands to PEGylated Au NPs (BP-PEG-Au NPs) resulted in five-fold greater binding affinity …

    Date Published:
    2018
    Record Visibility:
    Public
  • Author(s):
    Ryan K. Roeder, Tyler E. Curtis, Prakash D. Nallathamby, Lisa E. Irimata, Tracie L. McGinnity, Lisa E. Cole, Tracy Vargo-Gogola, Karen D. Cowden Dahl
    Abstract:

    Precision imaging is needed to realize precision medicine in cancer detection and treatment. Molecular imaging offers the ability to target and identify tumors, associated abnormalities, and specific cell populations with overexpressed receptors. Nuclear imaging and radionuclide probes provide high sensitivity but subject the patient to a high radiation dose and provide limited spatiotemporal information, requiring combined computed tomography (CT) for anatomic imaging. Therefore, nanoparticl…

    Date Published:
    2017
    Record Visibility:
    Public