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  • Author(s):
    Zhuxin Dong, Jae Hyde Park, Eamonn Kennedy, Mohammad Hokmabadi, Lisa Almonte-Garcia, Li Ding, Narayana Aluru, Gregory Timp

    The size of an ion affects everything from the structure of water to life itself. In this report, to gauge their size, ions dissolved in water are forced electrically through a sub-nanometer- diameter pore spanning a thin membrane and the current is measured. The measurements reveal an ion-selective conductance that vanishes in pores <0.24 nm in diameter—the size of a water molecule—indicating that permeating ions have a grossly distorted hydration shell. Analysis of the current noise powe…

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  • Author(s):
    Gregory Timp, Eamonn Kennedy, Zhuxin Dong, Clare Tennant

    Disclosed are then inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to protein denaturing agents, and may be employed in analytical and clinical methods for identifying single amino acid residues within the sequence of a protein and the pores are other than NspA pores. Methods for making a thin inorganic membrane with nanopore and sub-nanopore topography and conical cone stru…

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