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  • Author(s):
    Mikala Narlock, Pat Lawton, Patrick Rader
    Abstract:

    At Hesburgh Libraries at the University of Notre Dame, digitization had been an obscure process: roles and responsibilities were unclear, capacity was opaque, and institutional capabilities were mostly unknown. Col- lections were being digitized, but many were unclear how to go about it and what the possibilities were. Some characterized what had evolved as a “favor-based” system. To resolve these uncertainties, the Digital Collections Workflow (DCW) Team was established and charged with ensu…

    Date Published:
    2019-10
  • Author(s):
    Jeff Harden
    Abstract:

    Politicians and scholars contend that governmental transparency reforms constrain politicians’ capacity to negotiate and compromise in the pursuit of policy goals. However, existing research primarily emphasizes only that governments are strategic in adopting these reforms; whether lawmakers actually incur the alleged costs of transparency remains an open question. We investigate this issue in the context of American state legislatures, many of which have become exempt from “sunshine…

  • Author(s):
    Brianna Norris-Mullins, Bruce J. Melancon, Miguel A. Morales, Mary Ann McDowell
    Abstract:

    Leishmania parasites are the causative agents of a wide spectrum of human diseases. The clinical mani- festations of leishmaniasis range from self-healing skin lesions to fatality. The World Health Organization has classed leishmaniasis as a category 1 neglected tropical disease. Leishmaniasis represents a major in- ternational health challenge, affecting 12 million people per year and with nearly 310 million people at risk. The first-line chemotherapies used to treat leishmaniasis are intrav…

    Date Published:
    2019-07
  • Author(s):
    Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

  • Author(s):
    Ryan Roeder
    Abstract:

    Quantitative material decomposition of multiple mixed, or spatially coincident, contrast agent (gadolinium and iodine) and tissue (calcium and water) compositions is demonstrated using photon-counting spectral computed tomography (CT). Material decomposition is performed using constrained maximum like- lihood estimation (MLE) in the image domain. MLE is calibrated by multiple linear regression of all pure material compositions, which exhibits a strong correlation (R2 > 0.91) between the me…

  • Author(s):
    J. Schiltz, Andrew Rosenberger, Todd Render, Bernice Aboud Gatrell, Haibo Qu, Colton Steiner, Paul McGinn, Steve Schmid
    Abstract:

    Ceramics have exceptional tribological performance in high wear applications, but susceptibility to brittle fracture requires expensive postprocessing, including hot isostatic pressing and polishing. Consequently, additive manufacturing (AM) represents a collection of potentially costsaving approaches for ceramic production. AM technologies have been demonstrated for oxide ceramics, but the performance of self-mated AM materials remains unknown and underscores a critical knowledge gap. Alumin…

    Date Published:
    2019-06
  • Author(s):
    Pierre C. Dagher, Evan L. Nichols, Cody J. Smith, Kenneth W. Dunn, Scott S. Howard
    Abstract:

    Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique by selecting adjacent phasor points and labeling their corresponding pixels with different colors. This phasor labeling process, however, is empirical and could lead to biased results. In this Letter, we present a novel and unbiased approach …

    Date Published:
    2019-08
  • Author(s):
    S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J-Y. Shin, A. McMillan, A. D. Dikina, F. He, Y. Lee, Y. Cheng, K. Umemori, P. C. Wong, H. Park, J. D. Boerckel, E. Alsberg
    Abstract:

    Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human mesenchymal condensations presenting transforming growth factor–β1 (TGF-β1) and/or bone morphogenetic protein-2 (BMP-2) from encapsulated microparticles promotes endochondral defect regeneration con…

  • Author(s):
    Christopher Smyth, Lee Walsh, Pavel Bolshakov, Massimo Catalano, Michael Schmidt, Brendan Sheehan, Rafik Addou, Luhua Wang, Jiyoung Kim, Moon Kim, Christopher Hinkle, Robert Wallace
    Abstract:

    Sc has been employed as an electron contact to a number of two-dimensional (2D) materials (e.g. MoS2, black phosphorous) and has enabled, at times, the lowest electron contact resistance. However, the extremely reactive nature of Sc leads to stringent processing requirements and metastable device performance with no true understanding of how to achieve consistent, high-performance Sc contacts. In this work, WSe2 transistors with impressive subthreshold slope (109 mV dec−1) and I ON/I OFF (106…

    Date Published:
    2019-07
  • Author(s):
    Christopher Smyth, Lee Walsh, Pavel Bolshakov, Massimo Catalano, Michael Schmidt, Brendan Sheehan, Rafik Addou, Luhua Wang, Jiyoung Kim, Moon Kim, Christopher Hinkle, Robert Wallace
    Abstract:

    Sc has been employed as an electron contact to a number of two-dimensional (2D) materials (e.g. MoS2, black phosphorous) and has enabled, at times, the lowest electron contact resistance. However, the extremely reactive nature of Sc leads to stringent processing requirements and metastable device performance with no true understanding of how to achieve consistent, high-performance Sc contacts. In this work, WSe2 transistors with impressive subthreshold slope (109 mV dec−1) and I ON/I OFF (106…

    Date Published:
    2019-07
  • Author(s):
    Sarah Peterson, Kyle Bibby
    Abstract:

    Fecal indicator bacteria currently employed for microbial water quality management are poor representatives of viruses. Viral water quality indicators have recently been proposed based on the human gut bacteriophage crAssphage and the food virus pepper mild mottle virus (PMMoV) due to their high abundance in sewage and association to human waste. Here, we develop a model relating crAssphage and PMMoV abundance to risk of swimmer illness in a recreational water contaminated with fresh, untreat…

    Date Published:
    2019-08
  • Author(s):
    Melissa Grupen-Shemansky, Paul Bohn
    Abstract:

    This report was developed under a DARPA contract for topic Atoms to products. Two primary goals were addressed in this project. In Focus Area 1 (Assembly Development) the goal was to assemble a 10 μm microelement consisting of an anisotropic lattice of ~5000 (~100 nm) dielectric nanoparticles (NPs) embedded in a polymer electrolyte. Successful completion of the objectives of this goal required that NPs be spatially located with nm-scale precision in a polymer matrix at scales up to ~10 μm (to…

    Date Published:
    2019-07