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List of files deposited in CurateND that match your search criteria
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- Inventor(s):
- Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
- Patent Number:
- US 8574470 B2
- Description:
Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer …
- Date Issued:
- 2013-11-05
- Record Visibility:
- Public
- Title
- Combustion synthesis to bond metal inserts to C-C composite surfaces
- Description
- Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer such that a second complementary mating surface is matched to the complementary mating surface, thereby forming a construct of the carbon-carbon composite piece 30, the powder layer, and the metal insert 20; placing the construct into a press and applying pressure to the construct to press together the carbon-carbon composite piece and the metal insert joined at their complementary surfaces; and applying an electrical current to the powder in the construct to initiate a metal-carbon reaction, thereby bonding the carbon-carbon composite piece 30 together the metal insert 20. The titanium powder particles may be from 25 to 100 microns in diameter, and the carbon powder (e.g., graphite particles) may be 0.1 to 1 microns in diameter.
- Creator
- Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent
-
- Inventor(s):
- Mark A. Suckow, William R. Wolter
- Patent Number:
- US 8846059 B2
- Description:
Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…
- Date Issued:
- 2014-09-30
- Record Visibility:
- Public
- Title
- Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer
- Description
- Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovarian tumor inhibiting compositions that include extracellular matrix tissue adjuvants.
- Creator
- Mark A. Suckow, William R. Wolter
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Steven Buechler
- Patent Number:
- US 9721067 B2
- Description:
An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a particular diseased state is likely to benefit from further disease treatment, or does not have a high probability of benefit with additional treatment. Four genetic probes are disclosed that target the MKI67, CDC6 and SPAG5 gene and gene products. The ER+ breast cancer patient population is stratified…
- Date Issued:
- 2017-08-01
- Record Visibility:
- Public
- Title
- Accelerated progression relapse test
- Description
- An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a particular diseased state is likely to benefit from further disease treatment, or does not have a high probability of benefit with additional treatment. Four genetic probes are disclosed that target the MKI67, CDC6 and SPAG5 gene and gene products. The ER+ breast cancer patient population is stratified into two groups, with the low gene expression group identifying the patient/patient group that is less likely to benefit from additional treatment measures, and a high gene expression group identifying the patient group that is more likely to benefit from additional treatment measures.
- Creator
- Steven Buechler
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Carol Tanner, Steven Ruggiero
- Patent Number:
- US 9447456 B2
- Description:
Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nucleic acid complex, without the use of nanobeads. In particular, the examples include providing a plurality of nucleic acid fragments and a species-specific oligonucleotide tags, measuring the size of the nucleic acid fragments and/or oligonucleotides to predetermine a standard distribution of the solution(s), introducing the oligonucleotides in a solution containing nucleic a…
- Date Issued:
- 2016-09-20
- Record Visibility:
- Public
- Title
- Systems and methods for bead-free detection of nucleotides
- Description
- Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nucleic acid complex, without the use of nanobeads. In particular, the examples include providing a plurality of nucleic acid fragments and a species-specific oligonucleotide tags, measuring the size of the nucleic acid fragments and/or oligonucleotides to predetermine a standard distribution of the solution(s), introducing the oligonucleotides in a solution containing nucleic acid target materials and/or non-target materials, and hybridizing the oligonucleotides with the species-specific target material if present in the solution. The size of the nucleic acid complexes in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nucleic acid complexes after hybridization to the standard distribution.
- Creator
- Carol Tanner, Steven Ruggiero
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Malcolm J. Fraser
- Patent Number:
- US 9707257 B2
- Description:
Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting…
- Date Issued:
- 2017-07-18
- Record Visibility:
- Public
- Title
- Anti-HIV group I introns and uses thereof in treating HIV infections
- Description
- Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting the immune system with cells expressing these antivirals prevents re-establishment of HIV infection from reservoirs in the re-established lymphocyte and macrophage populations. Over time, reservoirs will be depleted entirely, effectively eliminating the virus. In effect, this new type of antiviral can be used to cure HIV infections.
- Creator
- Malcolm J. Fraser
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Norman Dovichi, Liangliang Sun, Guijie Zhu
- Patent Number:
- US 9465014 B2
- Description:
The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
- Date Issued:
- 2016-10-11
- Record Visibility:
- Public
- Title
- High sensitivity electrospray interface
- Description
- The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
- Creator
- Norman Dovichi, Liangliang Sun, Guijie Zhu
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Allen H. Simpson, Gregory Vanderheyden, Alexander Mukasyan, Mark L. La Forest
- Patent Number:
- US 10100889 B2
- Description:
A brake disc rotor or stator is manufactured with slots in the interior face of the disc. A paste comprised of a fine powder of a carbide-forming metal along with fine carbon powder, suspended in an organic binder, is applied to the force-bearing areas in the rotor slot faces or the stator slot faces. The disc is then placed into a furnace in a nitrogen atmosphere and heated to the ignition temperature. When the furnace reaches the ignition temperature, a combustion reaction begins that creat…
- Date Issued:
- 2018-10-16
- Record Visibility:
- Public
- Title
- Reactive sintering to eliminate metal inserts in carbon-carbon brake discs
- Description
- A brake disc rotor or stator is manufactured with slots in the interior face of the disc. A paste comprised of a fine powder of a carbide-forming metal along with fine carbon powder, suspended in an organic binder, is applied to the force-bearing areas in the rotor slot faces or the stator slot faces. The disc is then placed into a furnace in a nitrogen atmosphere and heated to the ignition temperature. When the furnace reaches the ignition temperature, a combustion reaction begins that creates a molten liquid ceramic material on the slot face. Upon cooling, the resulting brake disc has a tough, hard, abrasion-resistant ceramic surface on the portion of the brake disc slot that bears pressure.
- Creator
- Allen H. Simpson, Gregory Vanderheyden, Alexander Mukasyan, Mark L. La Forest
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Behnam Sedighi, Michael Niemier, Xiaobo Sharon Hu, Joseph J. Nahas
- Patent Number:
- US 9362919 B1
- Description:
A Boolean gate includes at least one symmetric tunneling field-effect transistor (SymFET) for low-power information processing. SymFETs are ideal for applications that demand low power and have moderate speed requirements, and demonstrate better dynamic energy efficiency than CMOS circuits. Negative differential resistance (NDR) behavior of SymFETs leads to hysteresis in inverters and buffers, and can be used to build simple Schmitt-triggers. Further, pseudo-SymFET loads may be utilized in ci…
- Date Issued:
- 2016-06-07
- Record Visibility:
- Public
- Title
- Devices for utilizing symFETs for low-power information processing
- Description
- A Boolean gate includes at least one symmetric tunneling field-effect transistor (SymFET) for low-power information processing. SymFETs are ideal for applications that demand low power and have moderate speed requirements, and demonstrate better dynamic energy efficiency than CMOS circuits. Negative differential resistance (NDR) behavior of SymFETs leads to hysteresis in inverters and buffers, and can be used to build simple Schmitt-triggers. Further, pseudo-SymFET loads may be utilized in circuits similar to all-n-type or dynamic logic. For example, latches and flip-flops as well as NAND, NOR, IMPLY, and MAJORITY gates may employ SymFETs. Such SymFET-based devices require fewer transistors than static CMOS-based designs.
- Creator
- Behnam Sedighi, Michael Niemier, Xiaobo Sharon Hu, Joseph J. Nahas
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
- Patent Number:
- US 9045442 B2
- Description:
Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.
- Date Issued:
- 2015-06-02
- Record Visibility:
- Public
- Title
- Antibacterial compounds and methods of using same
- Description
- Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.
- Creator
- Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Fabio Semperlotti, Hongfei Zhu
- Patent Number:
- US 9437183 B2
- Description:
An embedded acoustic metamaterial lenses allows for ultrasonic beam-forming and high resolution identification of acoustic sources for structural health monitoring. The lenses design provides an alternative to conventional phased-array technology enabling the formation of steerable and collimated (or focused) ultrasonic beams by exploiting a single transducer. The ultrasonic beam can be steered by simply tuning the frequency of the excitation. Also, the embedded lens can be designed to achiev…
- Date Issued:
- 2016-09-06
- Record Visibility:
- Public
- Title
- Metamaterial based acoustic lenses for structural health monitoring
- Description
- An embedded acoustic metamaterial lenses allows for ultrasonic beam-forming and high resolution identification of acoustic sources for structural health monitoring. The lenses design provides an alternative to conventional phased-array technology enabling the formation of steerable and collimated (or focused) ultrasonic beams by exploiting a single transducer. The ultrasonic beam can be steered by simply tuning the frequency of the excitation. Also, the embedded lens can be designed to achieve sub-wavelength resolution to clustered acoustic sources which is a typical scenario encountered in incipient structural damage.
- Creator
- Fabio Semperlotti, Hongfei Zhu
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Richard E. Taylor
- Patent Number:
- US 8865761 B1
- Description:
The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
- Date Issued:
- 2014-10-21
- Record Visibility:
- Public
- Title
- Regulation of cholesterol homeostasis
- Description
- The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
- Creator
- Richard E. Taylor
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- James McGivney, Guijie Zhu, Norman Dovichi
- Patent Number:
- US 9159537 B2
- Description:
Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).
- Date Issued:
- 2015-10-13
- Record Visibility:
- Public
- Title
- Method for analyzing sample components
- Description
- Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).
- Creator
- James McGivney, Guijie Zhu, Norman Dovichi
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent