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  • Author(s):
    Elizabeth I. Harper 1,2,3, Tyvette S. Hilliard 1,2, Emma F. Sheedy, Preston Carey, Paul Wilkinson, Michael D. Siroky 1,2, Jing Yang 1,2, Elizabeth Agadi 1,2,3, Annemarie K. Leonard 1,2, Ethan Low 1,2, Yueying Liu 1,2, Arya Biragyn, Christina M. Annunziata, Mary Sharon Stack 1,2
    Abstract:

    Background Age is the most significant risk factor for ovarian cancer (OvCa), the deadliest gynecologic malignancy. Metastasizing OvCa cells adhere to the omentum, a peritoneal structure rich in collagen, adipocytes, and immune cells. Ultrastructural changes in the omentum and the omental collagen matrix with aging have not been evaluated. Aim The aim of this study was to test the hypothesis that age-related changes in collagen in the ovarian tumor microenvironment promote OvCa metastatic su…

    Date Published:
    2022-04-19
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    Public
  • Author(s):
    Tyvette S Hilliard 1, Brooke Kowalski, Kyle Iwamoto, Elizabeth A Agadi 1 2, Yueying Liu, Jing Yang, Marwa Asem 1, Yuliya Klymenko 2, Jeff Johnson, Zonggao Shi, Gifty Marfowaa, Madeleine G Yemc, Phillip Petrasko, M Sharon Stack 1 2
    Abstract:

    Mesothelin (MSLN), a glycoprotein normally expressed by mesothelial cells, is overexpressed in ovarian cancer (OvCa) suggesting a role in tumor progression, although the biological function is not fully understood. OvCa has a high mortality rate due to diagnosis at advanced stage disease with intraperitoneal metastasis. Tumor cells detach from the primary tumor as single cells or multicellular aggregates (MCAs) and attach to the mesothelium of organs within the peritoneal cavity producing wid…

    Date Published:
    2021-11-18
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    Public
  • Author(s):
    Anirban K Mitra, David A Davis, Sunil Tomar, Lynn Roy, Hilal Gurler, Jia Xie, Daniel D Lantvit, Horacio Cardenas, Fang Fang, Yueying Liu, Elizabeth Loughran, Jing Yang, M Sharon Stack, Robert E Emerson, Karen D Cowden Dahl, Maria V Barbolina, Kenneth P Nephew, Daniela Matei, Joanna E Burdette 2
    Abstract:

    Objective: Genomic studies of ovarian cancer (OC) cell lines frequently used in research revealed that these cells do not fully represent high-grade serous ovarian cancer (HGSOC), the most common OC histologic type. However, OC lines that appear to genomically resemble HGSOC have not been extensively used and their growth characteristics in murine xenografts are essentially unknown. Methods: To better understand growth patterns and characteristics of HGSOC cell lines in vivo, CAOV3, COV362, …

    Date Published:
    2015-08
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    Public
  • Author(s):
    Le Wang, Erica A Pawlak, Philip J Johnson, James K Belknap, Susan Eades, Sharon Stack, Helene Cousin, Samuel J Black
    Abstract:

    The digital laminae is a two layer tissue that attaches the distal phalanx to the inner hoof wall, thus suspending the horse’s axial skeleton in the hoof capsule. This tissue fails at the epidermal:dermal junction in laminitic horses, causing crippling disease. Basal epithelial cells line the laminar epidermal:dermal junction, undergo physiological change in laminitic horses, and lose versican gene expression. Versican gene expression is purportedly under control of the canonical Wnt sign…

    Date Published:
    2013-02-06
    Record Visibility:
    Public
  • Author(s):
    Jeff J Johnson, Daniel L Miller, Rong Jiang, Yueying Liu, Zonggao Shi, Laura Tarwater, Russell Williams, Rashna Balsara, Edward R Sauter, M Sharon Stack 8
    Abstract:

    Oral cancer is the sixth most common cause of death from cancer with an estimated 400, 000 deaths worldwide and a low (50%) 5-year survival rate. The most common form of oral cancer is oral squamous cell carcinoma (OSCC). OSCC is highly inflammatory and invasive, and the degree of inflammation correlates with tumor aggressiveness. The G protein-coupled receptor protease-activated receptor-2 (PAR-2) plays a key role in inflammation. PAR-2 is activated via proteolytic cleavage by trypsin-like s…

    Date Published:
    2016-03-25
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    Public
  • Author(s):
    Kyle A Lewellen, Matthew N Metzinger, Yueying Liu, M Sharon Stack
    Abstract:

    Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy in the United States. Mortality is due to diagnosis of 75% of women with late stage disease, when metastasis is already present. EOC is characterized by diffuse and widely disseminated intra-peritoneal metastasis. Cells shed from the primary tumor anchor in the mesothelium that lines the peritoneal cavity as well as in the omentum, resulting in multi-focal metastasis, often in the presence of peritoneal …

    Date Published:
    2016-07-18
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  • Author(s):
    Chen Wang, John T Norton, Supurna Ghosh, Julie Kim, Kazuo Fushimi, Jane Y Wu, M Sharon Stack, Sui Huang
    Abstract:

    RNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) is often increased in cancer cells. Although some data support that PTB promotes cancer, the functional contribution of PTB to the malignant phenotype remains to be clarified. Here we report that although PTB levels are generally increased in cancer cell lines from multiple origins and in endometrial adenocarcinoma tumors, there appears to be no correlation between PTB l…

    Date Published:
    2008-07-18
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  • Author(s):
    M J Ravosa, J Ning, D B Costley, A N Daniel, S R Stock, M S Stack
    Abstract:

    Compared to force-resisting elements of the mammalian feeding apparatus, data on jaw-muscle plasticity are less common. This hinders our understanding of the role of force-producing structures in craniofacial development and integration. Thus, we investigated fiber-type abundance and cross-sectional area in the masseter muscle of growing rabbits subjected to diet-induced variation in masticatory stresses. Three loading cohorts were obtained as weanlings and raised until adult on different die…

    Date Published:
    2010-03-01
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  • Author(s):
    N Sun, J Johnson, M S Stack, J Szajko, C Sander, R Rebuyon, A Deatsch, J Easton, C E Tanner, S T Ruggiero
    Abstract:

    We have measured the optical properties of cancer and normal whole cells and lysates using light transmission spectroscopy (LTS). LTS provides both the optical extinction coefficient in the wavelength range from 220 to 1100nm and (by spectral inversion using a Mie model) the particle distribution density in the size range from 1 to 3000nm. Our current work involves whole cells and lysates of cultured human oral cells in liquid suspension. We found systematic differences in the optical extinct…

    Date Published:
    2015-09-01
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    Public
  • Author(s):
    Natalie M Moss, Maria V Barbolina, Yueying Liu, Limin Sun, Hidayatullah G Munshi, M Sharon Stack
    Abstract:

    An early event in the metastasis of epithelial ovarian carcinoma is shedding of cells from the primary tumor into the peritoneal cavity followed by diffuse i.p. seeding of secondary lesions. Anchorage-independent metastatic cells are present as both single cells and multicellular aggregates (MCA), the latter of which adhere to and disaggregate on human mesothelial cell monolayers, subsequently forming invasive foci. Although this unique metastatic mechanism presents a distinct set of therapeu…

    Date Published:
    2009-09-01
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  • Author(s):
    Supurna Ghosh, Jennifer Koblinski, and M. Sharon Stack
    Abstract:

    Oral squamous cell carcinoma (OSCC) has 50% 5-year survival rate, highlighting our limited understanding of the molecular events that contribute to disease progression. Microarray analyses of primary oral tumors have identified urinary type plasminogen activator (uPA) and its receptor (uPAR) as key genes associated with human OSCC progression. The uPAR functions both as a proteinase receptor and an integrin ligand, modifying proteolysis, migration, integrin signaling and cellular transcriptio…

    Date Published:
    2010-02-01
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  • Author(s):
    Ying Dong, Yaowu He, Leonore de Boer, M Sharon Stack, John W Lumley, Judith A Clements, John D Hooper
    Abstract:

    Epidermal growth factor (EGF) activation of the EGF receptor (EGFR) is an important mediator of cell migration, and aberrant signaling via this system promotes a number of malignancies including ovarian cancer. We have identified the cell surface glycoprotein CDCP1 as a key regulator of EGF/EGFR-induced cell migration. We show that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role…

    Date Published:
    2012-03-23
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