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  • Author:
    Yuan Gong
    Advisory Committee:
    Meng Jiang, Adam Czajka, Christian Poellabauer, Taeho Jung
    Degree Area:
    Computer Science and Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-07-09
    Record Visibility:
    Public
  • Author:
    Joseph M. Chambers
    Advisory Committee:
    Rebecca A. Wingert
    Degree Area:
    Biological Sciences
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-07-01
    Record Visibility:
    Public
  • Author:
    Samantha Murray
    Advisory Committee:
    Lijuan Wang, Julie M. Braungart-Rieker, E. Mark Cummings
    Degree Area:
    Psychology
    Degree:
    Master of Arts
    Defense Date:
    2020-07-13
    Record Visibility:
    Public
  • Author(s):
    Zhongmou Chao, Kutay Sezginel, Ke Xu, Garrison Crouch, Abigale Gray, Christopher Wilmer, Paul Bohn, David Go, Susan Fillerton-Shirey
    Abstract:

    Silver nanofilament formation dynamics are reported for an ionic liquid (IL)-filled solid polymer electrolyte prepared by a direct-write process using a conductive atomic force microscope (C-AFM). Filaments are electrochemically formed at hundreds of xy locations on a ≈40 nm thick polymer electrolyte, polyethylene glycol diacrylate (PEGDA)/[BMIM]PF6. Although the formation time generally decreases with increasing bias from 0.7 to 3.0 V, an unexpected non-monotonic maximum is observed ≈2.0 V. …

    Date Published:
    2019-01
    Record Visibility:
    Public
  • Author(s):
    Jason Mason, Jordan A. Cockfield, Daniel Pape, Hannah Meissner, Michael Sokolowski, Taylor C. White, Jose Valentin Lopez, Juan Liu, Xiaojing Liu, Inmaculada martinez-Reyes, Navdeep Chandel, Jason Locasale, Zachary Schafer
    Abstract:

    Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that impact cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM-detachment. In addition to anoikis, loss of ECM-attachment causes profound alterations in cellular metabolism that can lead to anoikis-independent cell death. Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion …

    Date Published:
    2020-03
    Record Visibility:
    Public
  • Author:
    Sarah Elizabeth Coogan
    Advisory Committee:
    Romana Huk
    Degree Area:
    English
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-06-25
    Record Visibility:
    Public
  • Author:
    Foteini Dimakopoulou
    Advisory Committee:
    Peter Burns
    Degree Area:
    Civil and Environmental Engineering and Earth Sciences
    Degree:
    Master of Science in Earth Sciences
    Record Visibility:
    Public
  • Author:
    Kyle Dubiak
    Advisory Committee:
    Paul W Huber
    Degree Area:
    Chemistry and Biochemistry
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-06-17
    Record Visibility:
    Public
  • Author(s):
    Sasha Padilla-Coley, Hui Xu
    Abstract:

    hydrophobic (i.e., Hoechst 33342) dyes or drugs, including a binary dye/drug pair (i.e., indocyanine green/mitoxantrone). The core of HBPn, containing a mixture of uncharged 2-pentanone chains and 1,2,3-triazole rings, could be loaded with uncharged and very hydrophobic dyes (i.e., Nile Red) or drugs. Improved aqueous solubility of camptothecin was achieved 10-fold from 8.4 to 75 ng/mL. Additionally, cell toxicity studies showed that HBPn was able to release the camptothecin drug inside A549 …

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
    Abstract:

    Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author:
    Jeremy Davidheiser
    Advisory Committee:
    Yasmin H. Solomonescu
    Degree Area:
    English
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-06-22
    Record Visibility:
    Public
  • Author:
    William T. Barker
    Advisory Committee:
    Christian C. Melander
    Degree Area:
    Chemistry and Biochemistry
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-06-11
    Record Visibility:
    Public