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  • 1

    Presentation

    Author(s):
    Mikala Narlock
    Abstract:

    Since the publication of the “FAIR Guiding Principles for scientific data management and stewardship” (Wilkinson et al., 2016), a wide-variety of sciences, mathematics, and other data-intensive fields have utilized the principles to promote reusability of data and ensure the long-term preservation of valuable outputs. In particular, domain experts and leading researchers have organized hackathons and sprints to define FAIR for their specific domains. Similarly, these domain experts have creat…

    Date Created:
    2019-11-10
    Resource Type
    Presentation
  • Author(s):
    Gregory Timp, Eamonn Kennedy, Zhuxin Dong, Clare Tennant
    Abstract:

    Disclosed are then inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to protein denaturing agents, and may be employed in analytical and clinical methods for identifying single amino acid residues within the sequence of a protein and the pores are other than NspA pores. Methods for making a thin inorganic membrane with nanopore and sub-nanopore topography and conical cone stru…

    Date Created:
    2019-02-28
    Resource Type
    Document
  • Author(s):
    Gregory Timp, Eamonn Kennedy
    Abstract:

    Disclosed are then inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to protein denaturing agents, and may be employed in analytical and clinical methods for identifying single amino acid residues within the sequence of a protein and the pores are other than NspA pores. Methods for making a thin inorganic membrane with nanopore and sub-nanopore topography and conical cone stru…

    Date Created:
    2019-02-28
    Resource Type
    Document
  • Abstract:

    The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as ge…

    Date Created:
    2019-08-07
    Resource Type
    Document
  • Author(s):
    Thomas V. Merluzzi
    Abstract:

    This document contains all of the search strategies used in Merluzzi, Pustejovsky, Philip, Sohl, Berendsen, & Salsman. Meta-analysis of self-efficacy RCTs with cancer patients. Psycho-Oncology, 2019 The search was conducted by Mark Berendsen (Northwestern University Medical Library).

    Date Created:
    2019-07-09
    Resource Type
    Document
  • Author(s):
    Pat Lawton, Mikala Narlock, Patrick Rader
    Abstract:

    The process of moving digitized and born-digital materials from selection to recovery, discovery, and preservation, was ambiguous at Notre Dame, as a “favor system” had become the norm. To address the issue, the Digital Collections Workflow (DCW) team, comprised of individuals from units across the library, developed workflows based on representative and adaptable use cases. This collaborative process, fueled by shared experience, resulted in a low- tech “case manager” approach that ensures p…

    Date Created:
    2019-04-29
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Resource Type
    Presentation
  • Abstract:

    PNDP 1300: Program for the August 2, 1845 Graduation Ceremonies at the University of Notre Dame, Notre Dame, Indiana, United States of America

    Date Published:
    1845-08-02
    Resource Type
    Document