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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Author(s):
    Erika Hosselkus
    Abstract:

    Colonial Puebla de los Ángeles’ mixed population of Spaniards, creoles, Native Americans, and groups of African descent confronted death frequently. Epidemic disease combined with mundane illnesses and infirmities made dying a quotidian and familiar experience among all social groups. The city’s religious and secular officials recognized death as an important rite of passage and sponsored and supported scripted rituals of death designed to guide the soul to its final resting place. As they ai…

    Date Published:
    2017-04
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  • Author(s):
    Helen Hockx-Yu
    Abstract:

    Manuscript draft of a Book Review for the journal Internet Histories: Invisible Women, Data Bias in a World Designed for Men, Caroline Cirado Perez, Abrams Press (2019), New York, U.S. $27.00

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  • Author(s):
    Peggy Griesinger, Karl-Rainer Blumenthal, Julia Kim, Shira Peltzman, Vicky Steeves
    Abstract:

    The National Digital Stewardship Alliance surveyed practitioners in 2012 and again in 2017 to gauge, among other things, how satisfied they were with their organizations’ digital preservation function. This study seeks to understand what causes the high and rising levels of dissatisfaction that practitioners reported. We interviewed 21 digital stewards and asked them to describe the organizational context in which they work; to reflect on what aspects of their organizations’ approach to digit…

    Date Published:
    2020-08
    Record Visibility:
    Public
  • Author(s):
    Yujie Hu, Changzhen Wang, Ruiyang Li, Fahui Wang
    Abstract:

    Estimating a massive drive time matrix between locations is a practical but challenging task. The challenges include availability of reliable road network (including traffic) data, programming expertise, and access to high-performance computing resources. This research proposes a method for estimating a nationwide drive time matrix between ZIP code areas in the U.S. - a geographic unit at which many national datasets including health information are compiled and distributed. The method (1) do…

    Date Published:
    2020-06
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  • Author(s):
    Ji-Young Son, Kevin J. Lane, Marie Lynn Miranda, Michelle L. Bell
    Abstract:

    Understanding the environmental justice implications of the mortality impacts of air pollution exposure is a public health priority, as some subpopulations may face a disproportionate health burden. We examined which residential environmental and social factors may affect disparities in the air pollution-mortality relationship in North Carolina, US, using a time-stratified case-crossover design. Results indicate that air pollution poses a higher mortality risk for some persons (e.g., elderly)…

    Date Published:
    2020-03
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  • Author(s):
    Marie Lynn Miranda
    Abstract:

    In January 2020, the EPA plans to issue a supplement to its 2018 proposed rule, Strengthening Transparency in Regulatory Science. The revised rule may prohibit the EPA from using any research for which underlying raw data and models are not made public. In the December 6, 2019 issue of Science, Dr. Marie Lynn Miranda, Director of CEHI, provided explanation of why such a rule would jeopardize regulations that aim to keep the environment a safe place for all of us to live.

    Date Published:
    2019-06
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  • Author(s):
    Keith B. Naylor, Joshua Tootoo, Olga Yakusheva, Scott A. Shipman, Julie P. W. Bynum, Matthew A. Davis
    Abstract:

    Background - Growing physician maldistribution and population demographic shifts have contributed to large geographic variation in healthcare access and the emergence of advanced practice providers as contributors to the healthcare workforce. Current estimates of geographic accessibility of physicians and advanced practice providers rely on outdated “provider per capita” estimates that have shortcomings.

    Purpose - To apply state of the art methods to estimate spatial accessibility of physic…

    Date Published:
    2019-04
    Record Visibility:
    Public
  • Author(s):
    Matthew A. Davis, Olga Yakusheva, Haiyin Liu, Joshua Tootoo, Marita G. Titler, Julie P.W. Bynum
    Abstract:

    OBJECTIVES: Chiropractic care is a service that operates outside of the conventional medical system and is reimbursed by Medicare. Our objective was to examine the extent to which accessibility of chiropractic care affects spending on medical spine care among Medicare beneficiaries.

    STUDY DESIGN: Retrospective cohort study that used beneficiary relocation as a quasi-experiment.

    METHODS: We used a combination of national data on provider location and Medicare claims to perform a quasi-experi…

    Date Published:
    2019-08
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  • Creator(s):
    Varun Mannam
    Description:

    We created a small dataset to validate the lifetime denoising using the trained Noise2Noise-NBN model - the Fluorescence Microscopy Lifetime Denoising (FMLD) dataset - that is dedicated to perform the lifetime denoising from the noisy (raw) lifetime images.

    The dataset consists of 50 real fluorescence microscopy images obtained with custom-built two-photon microscope and representative fixed BPAE cell (F36924) samples. We use all 50 images for testing/inference. These images are captured wi…

    Date Created:
    2020-01-01
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    Public
  • Creator(s):
    Varun Mannam
    Description:

    We created a dataset - the Lifetime From Intensity (LFI) dataset - that is dedicated to estimate the lifetime from intensity images. The dataset consists of 156 real fluorescence microscopy images obtained with custom-built two-photon microscope and representative biological zebrafish samples. We use 140 images for training and 16 images for testing. These images are captured with 2 different excitation wavelengths (800 and 920 nm) and different power levels (5 mW and 8 mW).

    Date Created:
    2019-08-13
    Record Visibility:
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