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  • Author(s):
    Sasha Padilla-Coley, Hui Xu
    Abstract:

    hydrophobic (i.e., Hoechst 33342) dyes or drugs, including a binary dye/drug pair (i.e., indocyanine green/mitoxantrone). The core of HBPn, containing a mixture of uncharged 2-pentanone chains and 1,2,3-triazole rings, could be loaded with uncharged and very hydrophobic dyes (i.e., Nile Red) or drugs. Improved aqueous solubility of camptothecin was achieved 10-fold from 8.4 to 75 ng/mL. Additionally, cell toxicity studies showed that HBPn was able to release the camptothecin drug inside A549 …

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
    Abstract:

    Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author:
    Mallika S. Sarma
    Advisory Committee:
    Agustín Fuentes, Cara Ocobock, Lee T. Gettler, James J. McKenna
    Degree Area:
    Anthropology
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-05-05
    Record Visibility:
    Public
  • Author:
    Lina Cao
    Advisory Committee:
    Patrick J. Fay
    Degree Area:
    Electrical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2020-05-14
    Record Visibility:
    Public
  • Author(s):
    Jeff Harden
    Abstract:

    Governments around the world adopt transparency reforms to facilitate accountability. In principle, open proceedings provide citizens with valuable information to evaluate elected officials’ decisionmaking, which incentives lawmakers to follow mass preferences when choosing policies. However, the public’s general lack of knowledge and engagement with the political process may weaken the power of open information, and perhaps instead allow citizens and groups with extreme views to exer…

    Record Visibility:
    Public
  • Author(s):
    Brenna Moore
    Abstract:

    In early twentieth-century France, a vast network of artists, writers, and religious seekers were drawn to Roman Catholicism’s elaborate panoply of symbols centered on suffering. A preoccupation with affliction dominated the movement now known as the French Catholic revival, or the renouveau catholique—considered a watershed in the history of the modern Catholic Church and the “golden age” of French Catholicism. In Sacred Dread, Brenna Moore examines the life and writings o…

    Date Created:
    2012-12-15
    Record Visibility:
    Public
    Resource Type
    Book
  • Author(s):
    Robert P. Kraynak
    Abstract:

    Do Christianity and modern liberal democracy share a common moral vision, or are they opposed and even hostile to each other? In Christian Faith and Modern Democracy, Robert Kraynak challenges the commonly accepted view that Christianity is inherently compatible with modern democratic society. Contrary to conventional wisdom, Kraynak argues that there is no necessary connection between Christianity and any form of government and that, in many important respects, Christianity is weakened by …

    Date Created:
    2001-10-12
    Record Visibility:
    Public
    Resource Type
    Book
  • Author(s):
    Kenneth P. Serbin
    Abstract:

    Serbin also describes the conservative modernization of the clergy, effected through seminary education, in the late nineteenth and early twentieth centuries. Emphasizing discipline, the seminaries aimed to mold a new kind of priest-moral, isolated from politics and social entanglements, and, above all, obedient and celibate. However, the social, cultural, and religious upheavals of the 1960s and 1970s led students to reject the seminary. Seminarians worked to form a national union, and many …

    Date Created:
    2006-05-03
    Record Visibility:
    Public
    Resource Type
    Book
  • Abstract:

    This book presents key documents from the pre-1915 history of the extraterrestrial life debate. Introductions and commentaries accompany each source document, some of which are published here for the first time or in a new translation. Authors included are Aristotle, Lucretius, Aquinas, Nicholas of Cusa, Galileo, Kepler, Pascal, Fontenelle, Huygens, Newton, Pope, Voltaire, Kant, Paine, Chalmers, Darwin, Wallace, Dostoevski, Lowell, and Antoniadi, among others. Michael J. Crowe has compiled an…

    Date Created:
    2008-10-15
    Record Visibility:
    Public
    Resource Type
    Book
  • Author(s):
    Paul J. Wadell, C.P.
    Abstract:

    Friendship and the Moral Life is not simply a theoretical argument about how moral theology might be done if it took friendship more seriously. Rather, the book exhibits how without friendship, our lives are morally not worth living. The book begins with a consideration of why a new model of the moral life is needed. Wadell then examines the ethics of Aristotle, who viewed the moral life as based on a specific understanding of the purpose of being human, with friendship being an important f…

    Date Created:
    1994-03-16
    Record Visibility:
    Public
    Resource Type
    Book
  • Author(s):
    Gilbert C. Meilaender
    Abstract:

    In Faith and Faithfulness Gilbert C. Meilaender suggests that Christians should not try to develop an autonomous ethic; neither, however, need they deny the common ground that exists with those who stand in other traditions. He then discusses human nature as creaturely, sinful, and justified–using these categories to think about such topics as the relation of humans to their environment, the meaning of personhood, and the meaning of original sin.

    Date Created:
    1991-06-30
    Record Visibility:
    Public
    Resource Type
    Book
  • Author(s):
    Steven A. Long
    Abstract:

    Analogia Entis: On the Analogy of Being, Metaphysics, and the Act of Faith is an intellectually rigorous and systematic account of Thomas’s teaching regarding the analogy of being. Steven A. Long’s work stands in contradistinction to historical-doctrinal surveys and general introductions, retrieving by way of an interpretation of Aristotle and Aquinas the indispensable role that analogy of being plays for metaphysics and, consequently, for theology. In his later writings St. Thoma…

    Date Created:
    2011-11-30
    Record Visibility:
    Public
    Resource Type
    Book