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  • Inventor(s):
    Kent Walters, John G. Duman, Anthony S. Serianni
    Patent Number:
    US 8604002 B1
    Description:

    The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…

    Date Issued:
    2013-12-10
    Resource Type
    Patent
  • Inventor(s):
    Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
    Patent Number:
    US 8574470 B2
    Description:

    Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer …

    Date Issued:
    2013-11-05
    Resource Type
    Patent
  • Inventor(s):
    John Simon, Debdeep Jena, Huili (Grace) Xing
    Patent Number:
    US 8835998 B2
    Description:

    A compositionally graded semiconductor device and a method of making same are disclosed that provides an efficient p-type doping for wide bandgap semiconductors by exploiting electronic polarization within the crystalline lattice. The compositional graded semiconductor graded device includes a graded heterojunction interface that exhibits a 3D bound polarization-induced sheet charge that spreads in accordance with .rho..sub..pi.(z)=-.gradient.P(z), where .rho..sub..pi.(z) is a volume charge d…

    Date Issued:
    2014-09-16
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8802113 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-08-12
    Resource Type
    Patent
  • Inventor(s):
    Shramik Sengupta, Hsueh-Chia Chang
    Patent Number:
    US 8635028 B2
    Description:

    An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk cap…

    Date Issued:
    2014-01-21
    Resource Type
    Patent
  • Inventor(s):
    Berardi Sensale-Rodriguez, Huili (Grace) Xing, Rusen Yan, Michelle M. Kelly, Tian Fang, Debdeep Jena, Lei Liu
    Patent Number:
    US 8836446 B2
    Description:

    A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conduc…

    Date Issued:
    2014-09-16
    Resource Type
    Patent
  • Inventor(s):
    Timothy C. Ovaert
    Patent Number:
    US 8919066 B2
    Description:

    An apparatus including an impact surface and a plurality of spaced apart stiffening columns extending from an underside of the flooring plate. The columns remain substantially rigid up to a predetermined critical pressure and then buckle as the pressure increases. The columns are at least partially surrounded by a resilient underlayment. Deflection stops may extend from the flooring plate to prevent over-buckling and/or permanent deformation of the stiffening columns. In some examples, the de…

    Date Issued:
    2014-12-30
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, Michael C. Hiles
    Patent Number:
    US 8,778,362 B2
    Description:

    Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Zhou Yu, Evgeny Drapkin, Bruno Kristiaan Bernard De Man, Jean-Baptiste Thibault, Kai Zeng, Jiang Hsieh, Brian E. Nett, Debashish Pal, Lin Fu, Guangzhi Cao, Charles A. Bouman, Ken D. Sauer
    Patent Number:
    US 9020230 B2
    Description:

    A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective fun…

    Date Issued:
    2015-04-28
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Resource Type
    Patent
  • Inventor(s):
    Jason C. Hicks, Gregory T. Neumann
    Patent Number:
    US 8969599 B2
    Description:

    The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis.

    Date Issued:
    2015-03-03
    Resource Type
    Patent