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  • Inventor(s):
    Jeffrey W. Talley, Steven Larson, Lawrence G. Wolfe, Brian D. Fisher
    Patent Number:
    US 8748331 B2
    Description:

    A method of manufacturing a remediation material uses a biogenic material as a substrate and involves preparing the surface of the substrate to enable a chemical reaction, and performing template-driven surface derivatization on the substrate to provide a net positive charge on the substrate. The remediation material may be placed into contact with surface water, ground water, soil, or sediment by at least one of a permeable reactive barrier, direct well injection, or direct introduction of t…

    Date Issued:
    2014-06-10
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8802113 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-08-12
    Resource Type
    Patent
  • Inventor(s):
    John Simon, Debdeep Jena, Huili (Grace) Xing
    Patent Number:
    US 8835998 B2
    Description:

    A compositionally graded semiconductor device and a method of making same are disclosed that provides an efficient p-type doping for wide bandgap semiconductors by exploiting electronic polarization within the crystalline lattice. The compositional graded semiconductor graded device includes a graded heterojunction interface that exhibits a 3D bound polarization-induced sheet charge that spreads in accordance with .rho..sub..pi.(z)=-.gradient.P(z), where .rho..sub..pi.(z) is a volume charge d…

    Date Issued:
    2014-09-16
    Resource Type
    Patent
  • Inventor(s):
    Berardi Sensale-Rodriguez, Huili (Grace) Xing, Rusen Yan, Michelle M. Kelly, Tian Fang, Debdeep Jena, Lei Liu
    Patent Number:
    US 8836446 B2
    Description:

    A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conduc…

    Date Issued:
    2014-09-16
    Resource Type
    Patent
  • Inventor(s):
    Brian G. Pierce, Zhiping Weng, Brian M. Baker
    Patent Number:
    US 9717758 B2
    Description:

    High-affinity variants of the DMF5 TCR, and methods of use thereof for the treatment and imaging of cancer in a patient.

    Date Issued:
    2017-08-01
    Resource Type
    Patent
  • Inventor(s):
    J. Nicholas Laneman, Zhanwei Sun, Glenn Bradford
    Patent Number:
    US 8838520 B2
    Description:

    In one embodiment, a cognitive radio dynamic spectrum access sensing system is configured to incorporate a hidden Markov model and a risk function to determine the primary user state sequence with the minimum amount of associated risk. The system comprises one or more weighted cost factors that can be used to handle a missed detection sensing error differently from a false alarm sensing error. The system further comprises a complete forward partial backward computation designed to increase se…

    Date Issued:
    2014-09-16
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler
    Patent Number:
    US 9721067 B2
    Description:

    An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a particular diseased state is likely to benefit from further disease treatment, or does not have a high probability of benefit with additional treatment. Four genetic probes are disclosed that target the MKI67, CDC6 and SPAG5 gene and gene products. The ER+ breast cancer patient population is stratified…

    Date Issued:
    2017-08-01
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Renee Bouley
    Patent Number:
    US 9,776,975 B2
    Description:

    A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding…

    Date Issued:
    2017-10-03
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Resource Type
    Patent
  • Inventor(s):
    Zachary Schultz, Oluwatosin Dada, Pierre Negri, Kevin Jacobs
    Patent Number:
    US 9,804,093 B2
    Description:

    The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection analysis, electrophoresis, and chromatography. A surface-enhanced Raman scattering (SERS) flow detector capable of ultrasensitive optical detection on the millisecond time scale has been developed. The device employs hydrodynamic focusing to improve SERS detection in a flow channel where a sheath flow confin…

    Date Issued:
    2017-10-31
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Resource Type
    Patent
  • Inventor(s):
    Behnam Sedighi, Xiaobo Sharon Hu, Michael Niemier, Joseph J. Nahas
    Patent Number:
    US 9825132 B2
    Description:

    An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (TFETs) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of the TFETs that is not on an end of the matrix, a drain of the TFET is electrically coupled with the source of at least one of the other TFETs at a node of the matrix and a source of the TFET is electrically coupled with the drain of at least one of the other TFETs at another node of the matrix. The ele…

    Date Issued:
    2017-11-21
    Resource Type
    Patent