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  • Inventor(s):
    Kent Walters, John G. Duman, Anthony S. Serianni
    Patent Number:
    US 8604002 B1
    Description:

    The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…

    Date Issued:
    2013-12-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
    Patent Number:
    US 8574470 B2
    Description:

    Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer …

    Date Issued:
    2013-11-05
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Jean-Baptiste Thibault, Xue Rui, Somesh Srivastava, Ken D. Sauer, Lin Fu, Charles A. Bouman
    Patent Number:
    US 9261467 B2
    Description:

    A system and method include acquisition of projection data from a scanned object, the set of projection data comprising a plurality of projection measurements. The system and method also include calculation of a set of modified statistical weights from the projection data, wherein a respective modified statistical weight of the set of modified statistical weights comprises a deviation from an inverse variance of a corresponding projection measurement of the projection data. The system and met…

    Date Issued:
    2016-02-16
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Jason C. Hicks, Gregory T. Neumann
    Patent Number:
    US 8969599 B2
    Description:

    The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis.

    Date Issued:
    2015-03-03
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Huili (Grace) Xing, Debdeep Jena, Kazuki Nomoto, Bo Song, Mingda Zhu, Zongyang Hu
    Patent Number:
    US 9362389 B2
    Description:

    A nitride-based field effect transistor (FET) comprises a compositionally graded and polarization induced doped p-layer underlying at least one gate contact and a compositionally graded and doped n-channel underlying a source contact. The n-channel is converted from the p-layer to the n-channel by ion implantation, a buffer underlies the doped p-layer and the n-channel, and a drain underlies the buffer.

    Date Issued:
    2016-06-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler
    Patent Number:
    US 9721067 B2
    Description:

    An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a particular diseased state is likely to benefit from further disease treatment, or does not have a high probability of benefit with additional treatment. Four genetic probes are disclosed that target the MKI67, CDC6 and SPAG5 gene and gene products. The ER+ breast cancer patient population is stratified…

    Date Issued:
    2017-08-01
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Carol Tanner, Steven Ruggiero
    Patent Number:
    US 9447456 B2
    Description:

    Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nucleic acid complex, without the use of nanobeads. In particular, the examples include providing a plurality of nucleic acid fragments and a species-specific oligonucleotide tags, measuring the size of the nucleic acid fragments and/or oligonucleotides to predetermine a standard distribution of the solution(s), introducing the oligonucleotides in a solution containing nucleic a…

    Date Issued:
    2016-09-20
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser
    Patent Number:
    US 9707257 B2
    Description:

    Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting…

    Date Issued:
    2017-07-18
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9465014 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-10-11
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9362102 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-06-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Valerie Sailes
    Patent Number:
    US 9283266 B2
    Description:

    Disclosed are compositions and pharmaceutical preparations suitable for inhibiting metastasis of a malignant cancer in an animal. Methods for inhibiting and/or eliminating metastasis in an animal are also provided. In some embodiments, the preparations and compositions comprise a whole cell tumor preparation comprising tumor tissue cells and tumor connective tissue stroma. The disclosure also provides methods for preparing the preparations and pharmaceutical preparations. Inhibition of metast…

    Date Issued:
    2016-03-15
    Record Visibility:
    Public
    Resource Type
    Patent