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- Inventor(s):
- Kent Walters, John G. Duman, Anthony S. Serianni
- Patent Number:
- US 8604002 B1
- Description:
The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…
- Date Issued:
- 2013-12-10
- Record Visibility:
- Public
- Title
- Saccharide antifreeze compositions
- Description
- The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: [missing image] (I) wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be used for a variety of industrial, agricultural, medical, and cosmetic applications where recrystallization-inhibition, cyroprotection, or cryopreservation is desired. The antifreeze glycolipid compounds or compositions can be used as, for example, as cryoprotectants for tissue preservation and transplantation, improving the texture of processed frozen food and frozen meats, frostbite protection, crop protection, and green alternatives for land vehicle antifreeze and aircraft de-icing.
- Creator
- Kent Walters, John G. Duman, Anthony S. Serianni
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent
-
- Inventor(s):
- Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
- Patent Number:
- US 8574470 B2
- Description:
Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer …
- Date Issued:
- 2013-11-05
- Record Visibility:
- Public
- Title
- Combustion synthesis to bond metal inserts to C-C composite surfaces
- Description
- Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer such that a second complementary mating surface is matched to the complementary mating surface, thereby forming a construct of the carbon-carbon composite piece 30, the powder layer, and the metal insert 20; placing the construct into a press and applying pressure to the construct to press together the carbon-carbon composite piece and the metal insert joined at their complementary surfaces; and applying an electrical current to the powder in the construct to initiate a metal-carbon reaction, thereby bonding the carbon-carbon composite piece 30 together the metal insert 20. The titanium powder particles may be from 25 to 100 microns in diameter, and the carbon powder (e.g., graphite particles) may be 0.1 to 1 microns in diameter.
- Creator
- Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent
-
- Inventor(s):
- John Simon, Debdeep Jena, Huili (Grace) Xing
- Patent Number:
- US 8835998 B2
- Description:
A compositionally graded semiconductor device and a method of making same are disclosed that provides an efficient p-type doping for wide bandgap semiconductors by exploiting electronic polarization within the crystalline lattice. The compositional graded semiconductor graded device includes a graded heterojunction interface that exhibits a 3D bound polarization-induced sheet charge that spreads in accordance with .rho..sub..pi.(z)=-.gradient.P(z), where .rho..sub..pi.(z) is a volume charge d…
- Date Issued:
- 2014-09-16
- Record Visibility:
- Public
- Title
- Compositionally graded heterojunction semiconductor device and method of making same
- Description
- A compositionally graded semiconductor device and a method of making same are disclosed that provides an efficient p-type doping for wide bandgap semiconductors by exploiting electronic polarization within the crystalline lattice. The compositional graded semiconductor graded device includes a graded heterojunction interface that exhibits a 3D bound polarization-induced sheet charge that spreads in accordance with .rho..sub..pi.(z)=-.gradient.P(z), where .rho..sub..pi.(z) is a volume charge density in a polar (z) direction, and .gradient. is a divergence operator, wherein the graded heterojunction interface is configured to exhibit substantially equivalent conductivities along both lateral and vertical directions relative to the graded heterojunction interface.
- Creator
- John Simon, Debdeep Jena, Huili (Grace) Xing
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Shramik Sengupta, Hsueh-Chia Chang
- Patent Number:
- US 8635028 B2
- Description:
An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk cap…
- Date Issued:
- 2014-01-21
- Record Visibility:
- Public
- Title
- Rapid detection of viable bacteria system and method
- Description
- An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.
- Creator
- Shramik Sengupta, Hsueh-Chia Chang
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent
-
- Inventor(s):
- Berardi Sensale-Rodriguez, Huili (Grace) Xing, Rusen Yan, Michelle M. Kelly, Tian Fang, Debdeep Jena, Lei Liu
- Patent Number:
- US 8836446 B2
- Description:
A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conduc…
- Date Issued:
- 2014-09-16
- Record Visibility:
- Public
- Title
- Methods and apparatus for terahertz wave amplitude modulation
- Description
- A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conductivity thereof, and the change in the optical conductivity of the layers of electrons causes an amplitude modulation of the transmitted electromagnetic wave passing through the capacitively coupled layers of electrons.
- Creator
- Berardi Sensale-Rodriguez, Huili (Grace) Xing, Rusen Yan, Michelle M. Kelly, Tian Fang, Debdeep Jena, Lei Liu
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Mark A. Suckow, William R. Wolter
- Patent Number:
- US 8802113 B2
- Description:
Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…
- Date Issued:
- 2014-08-12
- Record Visibility:
- Public
- Title
- Extracellular matrix cancer vaccine adjuvant
- Description
- Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), trocar, or other solid or semi-solid preparation. The invention provides for enhanced tumor inhibition of 2-fold or greater, compared to vaccine preparations without the extracellular matrix material, or from 4- to 5-fold, compared to preparations without the adjuvant promoting extracellular materials.
- Creator
- Mark A. Suckow, William R. Wolter
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Timothy C. Ovaert
- Patent Number:
- US 8919066 B2
- Description:
An apparatus including an impact surface and a plurality of spaced apart stiffening columns extending from an underside of the flooring plate. The columns remain substantially rigid up to a predetermined critical pressure and then buckle as the pressure increases. The columns are at least partially surrounded by a resilient underlayment. Deflection stops may extend from the flooring plate to prevent over-buckling and/or permanent deformation of the stiffening columns. In some examples, the de…
- Date Issued:
- 2014-12-30
- Record Visibility:
- Public
- Title
- Flooring apparatus for reducing impact energy during a fall
- Description
- An apparatus including an impact surface and a plurality of spaced apart stiffening columns extending from an underside of the flooring plate. The columns remain substantially rigid up to a predetermined critical pressure and then buckle as the pressure increases. The columns are at least partially surrounded by a resilient underlayment. Deflection stops may extend from the flooring plate to prevent over-buckling and/or permanent deformation of the stiffening columns. In some examples, the deflections stops may assist the floor in providing a substantially rigid surface at very high pressures.
- Creator
- Timothy C. Ovaert
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Shahriar Mobashery, Dusan Hesek, Mayland Chang
- Patent Number:
- US 8859620 B2
- Description:
The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…
- Date Issued:
- 2014-10-14
- Record Visibility:
- Public
- Title
- Phthalanilate compounds and methods of use
- Description
- The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo.
- Creator
- Shahriar Mobashery, Dusan Hesek, Mayland Chang
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Mark A. Suckow, Michael C. Hiles
- Patent Number:
- US 8,778,362 B2
- Description:
Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti…
- Date Issued:
- 2014-07-15
- Record Visibility:
- Public
- Title
- Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof
- Description
- Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer.
- Creator
- Mark A. Suckow, Michael C. Hiles
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type
- Patent
-
- Inventor(s):
- Zhou Yu, Evgeny Drapkin, Bruno Kristiaan Bernard De Man, Jean-Baptiste Thibault, Kai Zeng, Jiang Hsieh, Brian E. Nett, Debashish Pal, Lin Fu, Guangzhi Cao, Charles A. Bouman, Ken D. Sauer
- Patent Number:
- US 9020230 B2
- Description:
A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective fun…
- Date Issued:
- 2015-04-28
- Record Visibility:
- Public
- Title
- Method and apparatus for iterative reconstruction
- Description
- A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective function approximating the outer loop objective function, and an outer loop that utilizes the solution of the inner loop to optimize the original objective function.
- Creator
- Zhou Yu, Evgeny Drapkin, Bruno Kristiaan Bernard De Man, Jean-Baptiste Thibault, Kai Zeng, Jiang Hsieh, Brian E. Nett, Debashish Pal, Lin Fu, Guangzhi Cao, Charles A. Bouman, Ken D. Sauer
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Mark A. Suckow, William R. Wolter
- Patent Number:
- US 8846059 B2
- Description:
Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…
- Date Issued:
- 2014-09-30
- Record Visibility:
- Public
- Title
- Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer
- Description
- Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovarian tumor inhibiting compositions that include extracellular matrix tissue adjuvants.
- Creator
- Mark A. Suckow, William R. Wolter
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent
-
- Inventor(s):
- Jason C. Hicks, Gregory T. Neumann
- Patent Number:
- US 8969599 B2
- Description:
The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis.
- Date Issued:
- 2015-03-03
- Record Visibility:
- Public
- Title
- Cerium-containing zeolites and coke reduction methods
- Description
- The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis.
- Creator
- Jason C. Hicks, Gregory T. Neumann
- Publisher
- U.S. Patent and Trademark Office
- Language
- English
- Rights
- All rights reserved
- Resource Type
- Patent