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  • Inventor(s):
    Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
    Patent Number:
    US 9321692 B2
    Description:

    Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current …

    Date Issued:
    2016-04-26
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9220770 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2015-12-29
    Resource Type
    Patent
  • Inventor(s):
    Behnam Sedighi, Michael Niemier, Xiaobo Sharon Hu, Joseph J. Nahas
    Patent Number:
    US 9362919 B1
    Description:

    A Boolean gate includes at least one symmetric tunneling field-effect transistor (SymFET) for low-power information processing. SymFETs are ideal for applications that demand low power and have moderate speed requirements, and demonstrate better dynamic energy efficiency than CMOS circuits. Negative differential resistance (NDR) behavior of SymFETs leads to hysteresis in inverters and buffers, and can be used to build simple Schmitt-triggers. Further, pseudo-SymFET loads may be utilized in ci…

    Date Issued:
    2016-06-07
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
    Patent Number:
    US 9045442 B2
    Description:

    Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.

    Date Issued:
    2015-06-02
    Resource Type
    Patent
  • Inventor(s):
    Boldizsár Jankó, Cynthia Reichhardt, Charles Reichhardt, Dipanjan Ray
    Patent Number:
    US 9082923 B2
    Description:

    Disclosed is a method and apparatus for strongly enhancing vortex pinning by conformal crystal arrays. The conformal crystal array is constructed by a conformal transformation of a hexagonal lattice, producing a non-uniform structure with a gradient where the local six-fold coordination of the pinning sites is preserved, and with an arching effect. The conformal pinning arrays produce significantly enhanced vortex pinning over a much wider range of field than that found for other vortex pinni…

    Date Issued:
    2015-07-14
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 9321754 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2016-04-26
    Resource Type
    Patent
  • Inventor(s):
    Mehul Patel, Thomas C. Corke, Alan B. Cain
    Patent Number:
    US 9541106 B1
    Description:

    The present invention relates to a method of designing or optimizing a control surface for use with plasma actuators for controlling an aircraft, missile, munition or automobile, and more particularly to controlling fluid flow across their surfaces or other surfaces using plasma actuators, which would benefit from such a method. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and automobiles. The method of flow control also provides a mean…

    Date Issued:
    2017-01-10
    Resource Type
    Patent
  • Inventor(s):
    Ryan K. Roeder, Matthew J. Meagher, Robert J. Kane
    Patent Number:
    US 9550012 B2
    Description:

    The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of t…

    Date Issued:
    2017-01-24
    Resource Type
    Patent
  • Inventor(s):
    Steven Ruggiero, Carol Tanner
    Patent Number:
    US 9366612 B2
    Description:

    An apparatus for obtaining suspended particle information includes an optical array to divide light to a first path and a second path, a platform to orient a first and second container with either the first or second path, and a first and second photodetector to receive at least a direct illuminating component of the light of the first and second path after said light penetrates through the first and second container. A detector interface receives transmission signals from the first and secon…

    Date Issued:
    2016-06-14
    Resource Type
    Patent
  • Inventor(s):
    Jean-Baptiste Thibault, Xue Rui, Somesh Srivastava, Ken D. Sauer, Lin Fu, Charles A. Bouman
    Patent Number:
    US 9261467 B2
    Description:

    A system and method include acquisition of projection data from a scanned object, the set of projection data comprising a plurality of projection measurements. The system and method also include calculation of a set of modified statistical weights from the projection data, wherein a respective modified statistical weight of the set of modified statistical weights comprises a deviation from an inverse variance of a corresponding projection measurement of the projection data. The system and met…

    Date Issued:
    2016-02-16
    Resource Type
    Patent
  • Inventor(s):
    Wolfgang Porod, Gary H. Bernstein, Alexei Orlov, Gergo P. Szakmany
    Patent Number:
    US 9577173 B2
    Description:

    Nanoscale thermocouples are made of a single material and are shape-engineered to contain one or more variations in their width along their length. The mono-metallic nanowire junctions resulting from the width variation(s) exploit a difference in the Seebeck coefficient that is present at these size scales. Such devices have a wide variety of uses and can be coupled with an antenna in order to serve as an infrared detector.

    Date Issued:
    2017-02-21
    Resource Type
    Patent
  • Inventor(s):
    Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
    Patent Number:
    US 9333222 B2
    Description:

    Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.

    Date Issued:
    2016-05-10
    Resource Type
    Patent