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  • Author(s):
    Marwa Asem, Allison Young, Carlysa Oyama, Alejandro ClaureDeLaZerda, Yueying Liu, Matthew Ravosa, Vijayalaxmi Gupta, Andrea Jewell, Dineo Khabele, Sharon Stack
    Abstract:

    The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of ascites-induced compression on ovarian tumor cells and…

    Date Published:
    2020-07
    Record Visibility:
    Public
  • Author(s):
    Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
    Abstract:

    Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…

    Date Published:
    2020-04
    Record Visibility:
    Public