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  • Author(s):
    Anna McDermott, Samuel Herberg, Devon Mason, Joseph Collins, Hope Pearson, James Dawahare, Rui Tang, Amit N. Patwa, Mark Grinstaff, Daniel Kelly, Even Alsberg, Joel Boerckel
    Abstract:

    Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature bone. However, natural fracture healing is most efficient when it recapitulates development, forming bone via a cartilage intermediate (endochondral ossification). Because mechanical forces are critical for proper endochondral bone development and fracture repair, we hypothesi…

    Date Published:
    2019-06
    Record Visibility:
    Public
  • Author(s):
    Francesca Manzoni, Claudia Muller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia Finnegan
    Abstract:

    Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(II)-dipicolylamine (Zn-DPA) with Texas-red (PSVue-550) in transiently labeling apoptotic photoreceptors in living pigmented or albino rats and mice with retinal degeneration. Applying PSVue-550 as eyedrop is non-toxic and eliminates need for intraocular in…

    Date Published:
    2019-02
    Record Visibility:
    Public