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  • Author(s):
    Margo Waters, Veronica Kalwajtys, Katelyn Carothers, Ryan Roeder, Joshua Shrout, Shaun Lee, Prakash Nallathamby
    Abstract:

    The increasing frequency of nosocomial infections caused by antibiotic-resistant microorganisms concurrent with the stagnant discovery of new classes of antibiotics has made the development of new antibacterial agents a critical priority. Our approach is an antibiotic-free strategy drawing inspiration from bacteriophages to combat antibiotic-resistant bacteria. We developed a nanoparticle-based antibacterial system that structurally mimics the protein-turret distribution on the head structure…

    Date Published:
    2019-10
    Record Visibility:
    Public
  • Author(s):
    Wenzheng Kuang, Nicholas Kempf, Mortaza Saeidi-Javash, David Singh, Yanliang Zhang
    Abstract:

    Solution-processable semiconducting 2D nanoplates and 1D nanorods are attractive building blocks for diverse technologies, including thermoelectrics, optoelectronics, and electronics. However, transforming colloidal nanoparticles into high-performance and flexible devices remains a challenge. For example, flexible films prepared by solution-processed semiconducting nanocrystals are typically plagued by poor thermoelectric and electrical transport properties. Here, a highly scalable 3D conform…

    Date Published:
    2019-10
    Record Visibility:
    Public
  • Author(s):
    Sachwa Chong, Sergei M. Aksenov, Frabrice Dal Bo, Samuel N. Perry, Foteini Dimakopoulou, Peter C. Burns
    Abstract:

    Uranyl vanadate compounds with divalent cations, M(UO2)(V2O7) (M = Ca, Sr) and Sr3(UO2)(V2O7)2, were synthesized by flux crystal growth, and their crystal structures were solved using single-crystal X-ray diffraction data. Ca(UO2)V2O7 and Sr(UO2)V2O7 were synthesized from reactants with molar ratios M:U:V of 1:1:2 and identical heating conditions, and increasing the M:U:V ratio to 3:1:4 resulted in Sr3(UO2)(V2O7)2. Crystallographic data for M(UO2)V2O7 compounds are: a = 7.1774(18) Å, b = 6.77…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Karen Torosyan, Alexey Sedegov, Kirill Kuskov, Mohammad Abedi, Dmitry Arkhipov, Philipp Kiryukhamtsev-Korneer, Stepan Vorotilo, Dmitry Moskovskikh
    Abstract:

    The influence of different SPS-based methods, that is, conventional spark plasma sintering (SPS), flash SPS (FSPS), and reactive SPS (RSPS) on the properties of Al2O3/SiC composite was investigated. It was shown that the application of preliminary high energy ball milling of the powders significantly enhances the sinterability of the ceramics. It was also demonstrated that FSPS provides unique conditions for rapid, that is, less than a minute, consolidation of refractory ceramics. The Al2O3-2…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Angela Meola, Nicole Hondroglannis, Pierce Brown, Maksym Zhukovskyi, Zheng Zheng, Zeev Rosenzweig, Mary Sajini Devadas
    Abstract:

    Icosahedron and [Au25(PPh)10(C6H14S)5Cl2]2+ bi-icosahedron clusters were synthesized. Ligand exchange reactions were carried out with a new coumarin-derived fluorophore (Cou-SH) to label both clusters. Labeled and unlabeled Au25 were compared and the changes in the electronic structure were determined. The labeled clusters showed marked changes in electronic states, as evidenced by the quenching in the UV region and enhancement in the near infrared. The quantum yield from Cou-SH decreased and…

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Anna McDermott, Samuel Herberg, Devon Mason, Joseph Collins, Hope Pearson, James Dawahare, Rui Tang, Amit N. Patwa, Mark Grinstaff, Daniel Kelly, Even Alsberg, Joel Boerckel
    Abstract:

    Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature bone. However, natural fracture healing is most efficient when it recapitulates development, forming bone via a cartilage intermediate (endochondral ossification). Because mechanical forces are critical for proper endochondral bone development and fracture repair, we hypothesi…

    Date Published:
    2019-06
    Record Visibility:
    Public
  • Author(s):
    Francesca Manzoni, Claudia Muller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia Finnegan
    Abstract:

    Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(II)-dipicolylamine (Zn-DPA) with Texas-red (PSVue-550) in transiently labeling apoptotic photoreceptors in living pigmented or albino rats and mice with retinal degeneration. Applying PSVue-550 as eyedrop is non-toxic and eliminates need for intraocular in…

    Date Published:
    2019-02
    Record Visibility:
    Public
  • Author(s):
    Nydia Morales Soto, Anne E. Mattingly, Shaun W. Lee, Joshua D. Shrout
    Abstract:

    Many organisms coordinate to move and colonize over surfaces. Bacteria such as Pseudomonas aeruginosa exhibit such surface motility as a precursor step to forming biofilms. Here we show a group surface motility where small groups of P. aeruginosa use their type IV pili (TFP) appendages over long-distances. Small cell clusters employ their TFP to move multiple cell lengths in fractions of a second and form new multicellular groups. Given the length scale and speed of displacement, cells appear…

    Date Published:
    2019-01
    Record Visibility:
    Public
  • Author(s):
    Alyssa G. Oberman, Glen L. Niebur
    Abstract:

    Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone’s primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulated marrow. Understanding the effe…

    Date Published:
    2019-09
    Record Visibility:
    Public
  • Author(s):
    Alyssa G. Oberman, Glen L. Niebur
    Abstract:

    Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone’s primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulated marrow. Understanding the effe…

    Date Published:
    2019-09
    Record Visibility:
    Public
  • Author(s):
    Nydia Morales Soto, Anne E. Mattingly, Shaun W. Lee, Joshua D. Shrout
    Abstract:

    Many organisms coordinate to move and colonize over surfaces. Bacteria such as Pseudomonas aeruginosa exhibit such surface motility as a precursor step to forming biofilms. Here we show a group surface motility where small groups of P. aeruginosa use their type IV pili (TFP) appendages over long-distances. Small cell clusters employ their TFP to move multiple cell lengths in fractions of a second and form new multicellular groups. Given the length scale and speed of displacement, cells appear…

    Date Published:
    2019-01
    Record Visibility:
    Public
  • Author(s):
    Melissa Harden, Jeffrey J. Harden
    Abstract:

    What information can I trust? What sources should I include in my paper? Where can I find a quote that fits my argument? Undergraduates ask instructors, classmates, and/or librarians these questions. Meanwhile, instructors bemoan the gap between their expectations for student writing and the finished products. Navigating a large volume of scholarship and critically evaluating potential sources is straightforward for faculty who have long passed key information literacy thresholds. However, st…

    Date Published:
    2019
    Record Visibility:
    Public