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  • Author(s):
    Mikala Narlock, Peggy Griesinger
    Abstract:

    Presenters will describe the process of establishing formal project oversight for similar yet unique digital collections and projects. Attendees will be offered an inside look at the low-tech Case Manager approach, including helpful documentation, the variety of roles this process necessitates, and strategies for sustaining the practice.

    Date Created:
    2019-10-17
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Siyuang Zhang, Cody Smith, Scott Howard
    Abstract:

    Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence microscopy images, it is highly desirable to have effective denoising algorithms and datasets that are specifically designed to denoise fluorescence microscopy images. While su…

    Date Created:
    2019-10-15
    Resource Type
    Presentation
  • Author(s):
    Pat Lawton, Mikala Narlock, Patrick Rader
    Abstract:

    The process of moving digitized and born-digital materials from selection to recovery, discovery, and preservation, was ambiguous at Notre Dame, as a “favor system” had become the norm. To address the issue, the Digital Collections Workflow (DCW) team, comprised of individuals from units across the library, developed workflows based on representative and adaptable use cases. This collaborative process, fueled by shared experience, resulted in a low- tech “case manager” approach that ensures p…

    Date Created:
    2019-04-29
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Resource Type
    Presentation
  • Author(s):
    Thomas V. Merluzzi
    Abstract:

    Mastery Enhancement Therapy Improves Self-Efficacy, Depression, and Adjustment for Cancer Patients

    Raymond C. Nairn Thomas V. Merluzzi

    University of Notre Dame

    Mastery Enhancement Therapy (MET), which was developed by the authors, integrates solution focused therapy (Lindforss & Magnusson, 1997), self-regulation theory (Carver & Scheier, 1998), and self-efficacy theory (Bandura, 1997). We hypothesized that cancer patients who received MET would improve self-efficacy for coping wi…

    Date Created:
    2018-08-13
    Resource Type
    Presentation
  • Author(s):
    Tianze Peng, David Richter
    Abstract:

    Sea-spray droplets ejected into the air-sea boundary layer take part in a series of complex transport processes. To model the air-sea exchange of heat under high-wind conditions, it is important yet challenging to understand influences of evaporative droplets in the atmospheric boundary layer. We implement a high-resolution Eulerian-Lagrangian algorithm with varied droplets laden in a turbulent open-channel flow to reveal the dynamic and thermodynamic characteristics of droplets. Our past num…

    Date Created:
    2017-12-14
    Resource Type
    Presentation
  • Author(s):
    Mandy Havert, Jonathan D. Schwarz
    Abstract:

    The iconic Hesburgh Library building was nearing its 50th anniversary when review of the facilities program began in advance of renovation planning. This talk centers on graduate student workspaces, in particular closed study carrels that were characterized as ‘mop closets’ by some occupants. In 2013, review of existing data and feedback informed the initial planning for renovation of one tower floor in the library and its graduate student spaces. Through a series of focus groups, ope…

    Date Created:
    2017-10-10
    Resource Type
    Presentation
  • Author(s):
    Helen Hockx-Yu
    Abstract:

    Presentation given at iPres2017, the 14th International Conference on Digital Preservation which took place in Kyoto, Japan on September 25 – 29, 2017. It is based on a paper which was accepted by the conference https://curate.nd.edu/show/9p290863t3j.

    Date Created:
    2017-10-05
    Resource Type
    Presentation