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  • Author(s):
    Margaret L. Butzen, Jeremy B. Fein
    Abstract:

    In this study, we measured the effect of EPS on Cd and proton adsorption behaviors by measuring the extent of adsorption onto biomass with and without the EPS removed via a cation exchange resin. We conducted both Cd adsorption experiments and potentiometric titrations of biomass using three common bacterial species: one Gram-positive (Bacillus subtilis) and two Gram-negative (Shewanella oneidensis, Pseudomonas putida) species. The Cd adsorption experiments were con- ducted as a function of m…

    Date Published:
    2019-01
  • Author(s):
    Douglas Shoue, Brianna Norris-Mulliins, Bruce Melancon, Miguel A. Morales, Mary Ann McDowell
    Abstract:

    Leishmania parasites are the causative agents of a wide spectrum of human diseases. The clinical mani- festations of leishmaniasis range from self-healing skin lesions to fatality. The World Health Organization has classed leishmaniasis as a category 1 neglected tropical disease. Leishmaniasis represents a major international health challenge, affecting 12 million people per year and with nearly 310 million people at risk. The first-line chemotherapies used to treat leishmaniasis are intraven…

    Date Published:
    2019-07
  • Author(s):
    Eveline Rigo, Zhuxin Dong, Jae Hyun Park, Eamonn Kennedy, Mohammad Hokmabadi, Lisa Almonte-Garcia, Li Ding, Narayana Aluru, Gregory Timp
    Abstract:

    The size of an ion affects everything from the structure of water to life itself. In this report, to gauge their size, ions dissolved in water are forced electrically through a sub-nanometer- diameter pore spanning a thin membrane and the current is measured. The measurements reveal an ion-selective conductance that vanishes in poresThe size of an ion affects everything from the structure of water to life itself. In this report, to gauge their size, ions dissolved in water are forced electric…

    Date Published:
    2019-05
  • Author(s):
    Muhammad Ahmad, Chao Tang, Liu Yang, Andriy Yaroshchuk, Merlin Bruening
    Abstract:

    Development of anion-exchange membranes (AEMs) with selectivities among anions may expand the applications of these membranes in salt separations. This work shows that layer-by-layer coating of aliphatic polyamide AEMs with poly(4-styrenesulfonate) (PSS)/protonated poly(allylamine) (PAH) films enhances Cl − /SO 42− dialysis selectivities, and the extent of this enhancement depends on the source-phase salt concentrations. For a source phase containing 0.01 M NaCl and 0.01 M Na 2 SO 4 and a rec…

    Date Published:
    2019-02
  • Author(s):
    Chinedu Madukoma, Shusuke Tomoshige, Choonkeun Kim, Elan Lastochkin, William C. Boggess, Jed Fisher, Joshua Shrout, Shahriar Mobashery
    Abstract:

    The interplay between the activities of lytic transglycosylases (LTs) and penicillin-binding proteins (PBPs) is critical for the health of the bacterial cell wall. Bulgecin A (a natural-product inhibitor of LTs) potentiates the activity of β-lactam antibiotics (inhibitors of PBPs), underscoring this intimate mechanistic interdependence. Bulgecin A in the presence of an appropriate β-lactam causes bulge deformation due to the formation of aberrant peptidoglycan at the division site of the bact…

    Date Published:
    2019-01
  • Author(s):
    Seung-Ryong Kwon, Donghoon Han, Paul Bohn
    Abstract:

    Conspectus Electrochemical measurements conducted in confined volumes provide a powerful and direct means to address scientific questions at the nexus of nanoscience, biotechnology, and chemical analysis. How are electron transfer and ion transport coupled in confined volumes and how does understanding them require moving beyond macroscopic theories? Also, how do these coupled processes impact electrochemical detection and processing? We address these questions by studying a special type of c…

    Date Published:
    2019-10
  • Author(s):
    Holly Weiss-Bilka, Matthew Meagher, Joshua Gargac, Glen Niebur, Ryan Roeder, Diane Wagner
    Abstract:

    Background: Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with huma…

    Date Published:
    2019-07
  • Creator(s):
    Matthew Sisk
    Description:

    This is the data table from Appendix A of Sisk, ML (2011) “Settlement and Site Location in the Middle and Upper Paleolithic of the Vézère Valley, France” Ph.D. Dissertation, Stony Brook University, Department of Anthropology. It corrects errors present in the original publication

    Date Created:
    2020-02-12
  • Author(s):
    Trung T. Nguyen, Jeffrey Jones, Walter Wolter, Rocio Perez, Valerie Schroeder, Matthew Champion, Dusan Hesek, Mijoon Lee, Mark Suckow, Shahriar Mobashery, Mayland Chang
    Abstract:

    Diabetic foot ulcers are characterized by hypoxia. For many patients, hyperbaric oxygen (HBO) therapy is the last recourse for saving the limb from amputation, for which the molecular basis is not understood. We previously identified the active form of matrix metalloproteinase-9 (MMP-9) as responsible for diabetic foot ulcer’s recalcitrance to healing. Transcription of mmp-9 to the inactive zymogen is upregulated during hypoxia. Activation of the zymogen is promoted by proteases and react…

  • Author(s):
    Pius Adelani, Ginger E. Sigmon, Jennifer Szymanowski, Peter Burns
    Abstract:

    Two high nuclearity uranyl cages were crystallized in high yield under mild solvothermal conditions using rigid aryl phosphonate ligands. These compounds are prepared either through an in situ phosphonate ligand condensation reaction or via serendipitous assembly with a bulky phosphonate ligand. Firstly, the flexibility of the phosphonate ligands enhances the curvature of the uranyl polyhedra in the assembly of both compounds. Secondly, the formation of bent pyrophosphonate ligands through te…

    Date Published:
    2019-09
  • Creator(s):
    sgesing
    Description:

    In the Summer/Fall of 2017, participants were invited to contribute answers for the PresQT research study, entitled “Data and Software Preservation Quality Tool Needs Assessment” related to the PresQT Project, University of Notre Dame Study # 17-04-3850 DOI 10.17605/OSF.IO/D3JX7. Data Collection closed Sept 1, 2017 at 5 PM EDT.

    Participants’ answers to a series of questions related to their past practice, and anticipated future needs as researchers and/or software developers …

    Date Created:
    2020-01-27
  • Creator(s):
    Jonathan Hauenstein
    Description:

    Many algorithms for determining properties of real algebraic or semi-algebraic sets rely upon the ability to compute smooth points. Existing methods to compute smooth points on semi-algebraic sets use symbolic quantifier elimination tools. In this paper, we present a simple algorithm based on computing the critical points of some well-chosen function that guarantees the computation of smooth points in each connected compact component of a real (semi)-algebraic set. Our technique is intuitive …

    Date Created:
    2020-01-18