A Nonlinear Constitutive Model to Predict the Stress Strain Behavior of Small Intestinal Submucosa

Master's Thesis


Porcine small intestinal submucosa (SIS) is a bioactive resorbable extracellular matrix material (ECM) comprised mostly of collagen type I and containing the growth factors TGF-β and FGF-2. Current applications of this material consist of using SIS as a nonload-bearing device. However with its unique regenerative properties and nonlinear mechanical response, this material is a great choice for tendon or ligament replacement or repair. The development of this material to be used in a load-bearing application requires full understanding of its mechanical properties. A scaffold comprised of 20-layers of SIS sandwiched together was tested in a uniaxial tensile test. This test resulted in a nonlinearly elastic stress-strain response with a distinct toe-region, linear region, and strain to failure. To fully model this response, a nonlinear constitutive material model was developed using an exponential strain energy density function. As the ultimate tensile strength of this scaffold is lower than that of most tendons and ligaments, a polydiaxanone (PDS) mesh was incorporated into the 20-layer scaffold, which showed an increase in applied load with a decrease in ultimate tensile strength. In conclusion, a nonlinear constitutive model was developed to predict the nonlinear stress-strain response of a 20-layer multilaminate SIS scaffold which can serve as a building block to future development of a load-bearing bioresorbable scaffold.


Attribute NameValues
  • etd-07192006-222128

Author Brent Spanjersberg Mitchell
Advisor Glen L. Niebur
Contributor Ryan Roeder, Committee Member
Contributor Glen L. Niebur, Committee Chair
Contributor Diane Wagner, Committee Member
Degree Level Master's Thesis
Degree Discipline Aerospace and Mechanical Engineering
Degree Name MSME
Defense Date
  • 2006-06-15

Submission Date 2006-07-19
  • United States of America

  • nonlinear

  • SIS

  • small intestinal submucosa

  • Constitutive model

  • University of Notre Dame

  • English

Record Visibility Public
Content License
  • All rights reserved

Departments and Units


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