Effects of mechanobiological signaling in bone marrow on skeletal health



Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone’s primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulatedmarrow.Understanding the effects of thesemechanical inputs onmarrow function and adaptation requires knowledge of thematerial behavior of the marrow at multiple scales, the loads that are applied, and the mechanobiology of the cells. This paper reviews the current state of knowledge of each of these factors. Characterization of the marrow mechanical environment and its role in skeletal health and other marrow functions remains incomplete, but research on the topic is increasing, driven by interest in skeletal adaptation and the mechanobiology of cancer metastasis.


Attribute NameValues
  • Kimberly Curtis

  • Alyssa Oberman

  • Glen Niebur

Journal or Work Title
  • Annals of the New York Academy of Sciences

  • 12

  • 6

First Page
  • 1

Last Page
  • 14

Number of Pages
  • 14

  • 0077-8923

Publication Date
  • 2019-08

  • Nikon A1R

  • Wiley

Date Created
  • 2020-04-08

  • English

Departments and Units
Record Visibility Public
Content License
  • All rights reserved

Digital Object Identifier


This DOI is the best way to cite this article.