Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model

Article

Abstract

Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adipose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted.

Attributes

Attribute NameValues
Creator
  • Elizabeth A. Loughran

  • Ryan C. Phan

  • Annemarie K. Leonard

  • Laura Tarwater

  • Marwa Asem

  • Yueying Liu

  • Jing Yang

  • Yuliya Klymenko

  • Jeff Johnson

  • Zonggao Shi

  • Tyvette S. Hilliard

  • Marielle Blumenthaler

  • Matthew Leevy

  • Matthew J. Ravosa

  • M. Sharon Stack

Publication Date
  • 2017

Date Created
  • 2018-08-23

Language
  • English

Departments and Units
Record Visibility and Access Public
Content License
  • All rights reserved

Digital Object Identifier

doi:10.1016/j.canlet.2017.09.028

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