File(s) stored somewhere else
Please note: Linked content is NOT stored on University of Notre Dame and we can't guarantee its availability, quality, security or accept any liability.
Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model
journal contribution
posted on 2018-08-23, 00:00 authored by Annemarie K. Leonard, Elizabeth A. Loughran, Jeff Johnson, Jing YangJing Yang, Laura Tarwater, Sharon StackSharon Stack, Marielle Blumenthaler, Marwa Asem, Matthew J RavosaMatthew J Ravosa, Matthew Leevy, Ryan C. Phan, Tyvette S. Hillard, Yueying LiuYueying Liu, Yuliya KlymenkoYuliya Klymenko, Zonggao ShiZonggao ShiOvarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adipose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted.
History
Date Modified
2018-10-12Language
- English
Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC