Quinazolinone antibiotics

Patent

Description

A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding proteins and/or other important cellular targets. Methods for inhibiting the growth and/or replication of bacteria using the compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, including drug-resistant strains of Staphylococcus aureus.

Attributes

Attribute NameValues
Title
  • Quinazolinone antibiotics

Patent Number
  • US 9,776,975 B2

USPTO Link
Inventor
  • Mayland Chang

  • Shahriar Mobashery

  • Renee Bouley

Inventor From Local Institution
  • Mayland Chang

  • Shahriar Mobashery

  • Renee Bouley

Other Application
  • 14/773,603

Prior Publication Date
  • 2016-02-04

Prior Publication Number
  • US 20160031832 A1

Claims
  • 13

Cooperative Patent Classification codes
  • C07D 239/91 (20130101); A61K 31/43 (20130101); A61K 31/431 (20130101); A61K 31/517 (20130101); A61K 31/519 (20130101); A61K 31/5377 (20130101); A61K 31/545 (20130101); A61K 31/546 (20130101); A61K 31/7036 (20130101); A61K 31/7048 (20130101); A61K 45/06 (20130101); C07D 401/06 (20130101); C07D 401/12 (20130101); C07D 405/06 (20130101); C07D 471/04 (20130101); A61K 31/43 (20130101); A61K 31/431 (20130101); A61K 31/545 (20130101); A61K 31/546 (20130101); A61K 31/7036 (20130101); A61K 31/7048 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101)

International Patent Classification codes
  • A61K 31/517 (20060101); A61K 31/43 (20060101); A61K 45/06 (20060101); C07D 471/04 (20060101); C07D 405/06 (20060101); C07D 401/06 (20060101); C07D 239/91 (20060101); A61K 31/431 (20060101); C07D 401/12 (20060101); A61K 31/5377 (20060101); A61K 31/519 (20060101); A61K 31/7048 (20060101); A61K 31/7036 (20060101); A61K 31/546 (20060101); A61K 31/545 (20060101)

Language
  • English

Date Issued
  • 2017-10-03

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

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