9,776,975OCR.pdf (2.2 MB)
Quinazolinone antibiotics
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posted on 2017-11-30, 00:00 authored by Mayland ChangMayland Chang, Renee Bouley, Shahriar MobasheryShahriar MobasheryA new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding proteins and/or other important cellular targets. Methods for inhibiting the growth and/or replication of bacteria using the compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, including drug-resistant strains of Staphylococcus aureus.
History
Patent Number
US 9,776,975 B2Other Application
14/773,603Inventor
Mayland Chang Shahriar Mobashery Renee BouleyInventor from Local Institution
Mayland Chang Shahriar Mobashery Renee BouleyAssignee
University of Notre Dame du LacDate Modified
2017-11-30Language
- English
Claims
13Prior Publication Number
US 20160031832 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
C07D 239/91 (20130101); A61K 31/43 (20130101); A61K 31/431 (20130101); A61K 31/517 (20130101); A61K 31/519 (20130101); A61K 31/5377 (20130101); A61K 31/545 (20130101); A61K 31/546 (20130101); A61K 31/7036 (20130101); A61K 31/7048 (20130101); A61K 45/06 (20130101); C07D 401/06 (20130101); C07D 401/12 (20130101); C07D 405/06 (20130101); C07D 471/04 (20130101); A61K 31/43 (20130101); A61K 31/431 (20130101); A61K 31/545 (20130101); A61K 31/546 (20130101); A61K 31/7036 (20130101); A61K 31/7048 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101)Contributor
Mayland Chang|Shahriar Mobashery|Renee BouleyInternational Patent Classification Codes
A61K 31/517 (20060101); A61K 31/43 (20060101); A61K 45/06 (20060101); C07D 471/04 (20060101); C07D 405/06 (20060101); C07D 401/06 (20060101); C07D 239/91 (20060101); A61K 31/431 (20060101); C07D 401/12 (20060101); A61K 31/5377 (20060101); A61K 31/519 (20060101); A61K 31/7048 (20060101); A61K 31/7036 (20060101); A61K 31/546 (20060101); A61K 31/545 (20060101)Usage metrics
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