Breast cancer prognostication and screening kits and methods of using same

Patent

Description

A genetic biomarker panel is provided for prognosing late onset ER+ breast cancer relapse, in a breast cancer survivor patient. Kits are also provided for measuring levels or the presence of an identified panel of genetic biomarkers. Methods are also provided for identifying a breast cancer survivor patient at a relatively high risk of suffering a breast cancer relapse within 8 years of diagnosis, and therefore suitable for treatment with an aggressive chemotherapeutic regimen. The method may also be used for identifying a breast cancer survivor patient not at high risk of suffering a breast cancer relapse within 8 years of diagnosis, and thus not suitable for treatment with an aggressive chemotherapeutic regimen. The genetic biomarker panel includes an oligonucleotide/nucleic acid sequence specific for the following genes: MKI67, SPAG5, ESPL1, PLK1, or a genetic panel for MKI67, SPAG5, ESPL1, PLK1 and PGR.

Attributes

Attribute NameValues
Title
  • Breast cancer prognostication and screening kits and methods of using same

Patent Number
  • US 10174382 B2

USPTO Link
Inventor
  • Sunil Badve

  • Steven Buechler

  • Yesim Gokmen-Polar

Inventor From Local Institution
  • Steven Buechler

Other Application
  • 14/711,566

Prior Publication Date
  • 2016-11-17

Prior Publication Number
  • US 20160333413 A1

Claims
  • 5

Cooperative Patent Classification codes
  • C12Q 1/6886 (20130101); C12Q 2600/118 (20130101); C12Q 2600/158 (20130101)

International Patent Classification codes
  • C12Q 1/68 (20180101); C07H 21/04 (20060101); C12Q 1/6886 (20180101)

Language
  • English

Date Issued
  • 2019-01-08

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

  • Indiana University Research and Technology Corporation (Indianapolis)

Record Visibility and Access Public
Content License
  • All rights reserved

Departments and Units
Member of

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Collections Featuring this Patent
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