Regulation of cholesterol homeostasis

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Description

The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.

Attributes
Attribute NameValues
Title

  • Regulation of cholesterol homeostasis

Patent Number

  • US 8865761 B1

USPTO Link
Inventor

  • Richard E. Taylor

Inventor From Local Institution

  • Richard E. Taylor

Other Application

  • 13/961,659

Prior Publication Date

  • 2012-08-07

Prior Publication Number

  • 61742290

Claims

  • 18

Classification (US Patent)

  • 514/450; 514/451

Cooperative Patent Classification codes

  • C07D 407/06 (20130101); C07D 303/14 (20130101); C07D 309/06 (20130101); C07D 303/28 (20130101); A61K 31/351 (20130101); A61K 31/365 (20130101); A61K 9/0014 (20130101); A61K 9/0019 (20130101); A61K 47/02 (20130101); A61K 47/10 (20130101); A61K 47/32 (20130101); A61K 9/12 (20130101); A61K 9/2054 (20130101); A61K 9/4858 (20130101)

International Patent Classification codes

  • A61K 31/335 (20060101); A61K 31/351 (20060101)

Language

  • English

Date Issued

  • 2014-10-21

Publisher

  • U.S. Patent and Trademark Office

Assignee

  • University of Notre Dame du Lac

Record Visibility Public
Content License

  • All rights reserved

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