Advancing our understanding of biological phenomena can be carried out through two complementary approaches: modeling and simulation of biological processes and bioinformatic analysis of genomic data. Modeling and simulation serves to provide tests of the plausibility and robustness of proposed biological mechanisms, and they can suggest previously unknown but experimentally testable hypotheses from known biological interactions. Bioinformatic analysis strives to discover meaningful patterns from genomic and other data that serve as hypotheses about the structure and function of genome features and their relationship among organisms. This dissertation addresses the challenge of both approaches through modeling and simulation of limb chondrogenesis and novel algorithms and computational tools for multiple organism comparative genomics.
Modeling and Simulation of Vertebrate Limb Chondrogenesis and Algorithms for Comparative Genomics
Doctoral Dissertation
Abstract
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Author | Scott Christley |
Advisor | Bei Hu |
Contributor | Scott Emrich, Committee Member |
Contributor | Bei Hu, Committee Chair |
Contributor | Mark Alber, Committee Member |
Contributor | Jesus Izaguirre, Committee Member |
Contributor | Greg Madey, Committee Member |
Contributor | Frank Collins, Committee Member |
Degree Level | Doctoral Dissertation |
Degree Discipline | Computer Science and Engineering |
Degree Name | Doctor of Philosophy |
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Submission Date | 2008-04-16 |
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Record Visibility | Public |
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ChristleyS042008.pdf | 2.73 MB | application/pdf | Public |
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