Modeling and Simulation of Vertebrate Limb Chondrogenesis and Algorithms for Comparative Genomics

Doctoral Dissertation

Abstract

Advancing our understanding of biological phenomena can be carried out through two complementary approaches: modeling and simulation of biological processes and bioinformatic analysis of genomic data. Modeling and simulation serves to provide tests of the plausibility and robustness of proposed biological mechanisms, and they can suggest previously unknown but experimentally testable hypotheses from known biological interactions. Bioinformatic analysis strives to discover meaningful patterns from genomic and other data that serve as hypotheses about the structure and function of genome features and their relationship among organisms. This dissertation addresses the challenge of both approaches through modeling and simulation of limb chondrogenesis and novel algorithms and computational tools for multiple organism comparative genomics.

Attributes

Attribute NameValues
URN
  • etd-04162008-120704

Author Scott Christley
Advisor Bei Hu
Contributor Scott Emrich, Committee Member
Contributor Bei Hu, Committee Chair
Contributor Mark Alber, Committee Member
Contributor Jesus Izaguirre, Committee Member
Contributor Greg Madey, Committee Member
Contributor Frank Collins, Committee Member
Degree Level Doctoral Dissertation
Degree Discipline Computer Science and Engineering
Degree Name Doctor of Philosophy
Defense Date
  • 2008-03-18

Submission Date 2008-04-16
Country
  • United States of America

Subject
  • stochastic modeling

  • morphogenesis

  • bioinformatics

  • vertebrate development

  • agent-based modeling

Publisher
  • University of Notre Dame

Language
  • English

Record Visibility and Access Public
Content License
  • All rights reserved

Departments and Units

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