8,937,151 OCR.pdf (3.32 MB)
Gelatinase inhibitors and prodrugs
standard
posted on 2017-07-31, 00:00 authored by Mayland ChangMayland Chang, Mijoon Lee, Shahriar MobasheryShahriar MobasheryThe invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration.
History
Patent Number
US 8937151 B2Other Application
13/582,678Inventor
Mayland Chang Shahriar Mobashery Mijoon LeeInventor from Local Institution
Mayland Chang Shahriar Mobashery Mijoon LeeAssignee
University of Notre Dame du LacDate Modified
2017-08-01Language
- English
Claims
16Prior Publication Number
US 20130052184 A1Publisher
U.S. Patent and Trademark OfficeCooperative Patent Classification Codes
C07D 331/02 (20130101); C07D 409/12 (20130101); A61K 38/49 (20130101); A61K 38/4886 (20130101); A61K 38/482 (20130101); A61K 31/38 (20130101); C12Y 304/24017 (20130101); C12Y 304/24007 (20130101); C12Y 304/21073 (20130101); C12Y 304/21068 (20130101); C12Y 304/24035 (20130101); C12Y 304/24023 (20130101); C12Y 304/21 (20130101)Contributor
Mayland Chang|Shahriar Mobashery|Mijoon LeeInternational Patent Classification Codes
A61K 38/00 (20060101); C07K 16/00 (20060101); C07K 14/00 (20060101); C07K 5/00 (20060101); C07K 7/00 (20060101); C07K 2/00 (20060101); C07K 4/00 (20060101); C07K 17/00 (20060101)US Patent Classification Codes
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