University of Notre Dame
Browse
8,937,151 OCR.pdf (3.32 MB)

Gelatinase inhibitors and prodrugs

Download (3.32 MB)
standard
posted on 2017-07-31, 00:00 authored by Mayland ChangMayland Chang, Mijoon Lee, Shahriar MobasheryShahriar Mobashery
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration.

History

Patent Number

US 8937151 B2

Other Application

13/582,678

Inventor

Mayland Chang Shahriar Mobashery Mijoon Lee

Inventor from Local Institution

Mayland Chang Shahriar Mobashery Mijoon Lee

Assignee

University of Notre Dame du Lac

Date Modified

2017-08-01

Language

  • English

Claims

16

Prior Publication Number

US 20130052184 A1

Publisher

U.S. Patent and Trademark Office

Cooperative Patent Classification Codes

C07D 331/02 (20130101); C07D 409/12 (20130101); A61K 38/49 (20130101); A61K 38/4886 (20130101); A61K 38/482 (20130101); A61K 31/38 (20130101); C12Y 304/24017 (20130101); C12Y 304/24007 (20130101); C12Y 304/21073 (20130101); C12Y 304/21068 (20130101); C12Y 304/24035 (20130101); C12Y 304/24023 (20130101); C12Y 304/21 (20130101)

Contributor

Mayland Chang|Shahriar Mobashery|Mijoon Lee

International Patent Classification Codes

A61K 38/00 (20060101); C07K 16/00 (20060101); C07K 14/00 (20060101); C07K 5/00 (20060101); C07K 7/00 (20060101); C07K 2/00 (20060101); C07K 4/00 (20060101); C07K 17/00 (20060101)

US Patent Classification Codes

530/300

Usage metrics

    Patents

    Categories

    No categories selected

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC