Saccharide antifreeze compositions



The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be used for a variety of industrial, agricultural, medical, and cosmetic applications where recrystallization-inhibition, cyroprotection, or cryopreservation is desired. The antifreeze glycolipid compounds or compositions can be used as, for example, as cryoprotectants for tissue preservation and transplantation, improving the texture of processed frozen food and frozen meats, frostbite protection, crop protection, and green alternatives for land vehicle antifreeze and aircraft de-icing.


Attribute NameValues
  • Saccharide antifreeze compositions

Patent Number
  • US 8604002 B1

  • Kent Walters

  • John G. Duman

  • Anthony S. Serianni

Inventor From Local Institution
  • Kent Walters

  • John G. Duman

  • Anthony S. Serianni

Other Application
  • 13/135,065

Prior Publication Date
  • 2010-06-23

Prior Publication Number
  • 61398276

  • 26

Classification (US Patent)
  • 514/54; 106/13; 536/123.1

Cooperative Patent Classification codes
  • A61K 31/739 (20130101); C09K 3/185 (20130101); A61K 31/7016 (20130101); C08B 37/006 (20130101); C08L 5/00 (20130101)

International Patent Classification codes
  • A61K 31/739 (20060101); C08B 37/00 (20060101); C09K 3/18 (20060101)

  • English

Date Issued
  • 2013-12-10

  • U.S. Patent and Trademark Office

  • University of Notre Dame du Lac

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