Heterocyclic antituberculosis agents

Patent

Description

Method for treating tuberculosis with 2-(2-substituted-phenyl)-2-oxazolines and related 5-membered heterocycles represented by the formula ##STR1## Y.sub.1 is e.g. an ester or amide forming group, and X is O, S, or NH; and pharmaceutically acceptable formulations useful therein are provided. A preferred method comprises administering (S)-benzyl2-[2-(benzyloxy)phenyl]-2-oxazoline-4-carboxylate in a suitable formulation. The compounds of the above formula are prepared by known methods, e.g. the oxazolines are obtained by coupling a substituted benzoic acid with a serine ester or threonine ester and cyclizing the coupled product.

Attributes

Attribute NameValues
Title
  • Heterocyclic antituberculosis agents

Patent Number
  • US 6403623 B2

USPTO Link
Inventor
  • Marvin J. Miller

  • Jingdan Hu

Inventor From Local Institution
  • Marvin J. Miller

Other Application
  • 09/578,834

Claims
  • 16

Classification (US Patent)
  • 514/365; 514/374; 514/385; 514/924;

Cooperative Patent Classification codes
  • A61K 31/415 (20130101); A61K 31/425 (20130101); A61K 31/42 (20130101); Y10S 514/924 (20130101)

International Patent Classification codes
  • A61K 31/425 (20060101); A61K 31/415 (20060101); A61K 31/42 (20060101); A61K 031/425 (); A61K 031/42 (); A61K 031/415 ()

Language
  • eng

Date Issued
  • 2002-06-11

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

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Content License
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