University of Notre Dame
Browse
9,220,770 OCR.pdf (1.72 MB)

Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins

Download (1.72 MB)
standard
posted on 2017-08-01, 00:00 authored by Mark A. Suckow, Paul J. Hall, William R. Wolter
Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

History

Patent Number

US 9220770 B2

Other Application

12/868,908

Inventor

Mark A. Suckow William R. Wolter Paul J. Hall

Inventor from Local Institution

Mark A. Suckow William R. Wolter

Assignee

University of Notre Dame du Lac Cook Biotech, Inc. (West Lafayette, IN)

Date Modified

2017-08-01

Language

  • English

Claims

16

Prior Publication Number

2011-03-31

Publisher

U.S. Patent and Trademark Office

Cooperative Patent Classification Codes

A61K 39/08 (20130101); A61K 39/39 (20130101); A61K 2039/55511 (20130101); A61K 2039/55588 (20130101)

Contributor

Mark A. Suckow|William R. Wolter

International Patent Classification Codes

A61K 39/39 (20060101); A61K 39/00 (20060101); A61K 39/08 (20060101)

US Patent Classification Codes

1/1

Usage metrics

    Patents

    Categories

    No categories selected

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC