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Antimycobacterial agents

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posted on 2016-06-07, 00:00 authored by Marvin J MillerMarvin J Miller, Yanping Xu
Compounds represented by the formula [1] ##STR1## R.sub.1 is H or a substituent; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is siderophore group e.g. CH.sub.3 --(CH.sub.2).sub.n --C(O)--N(OH)--(CH.sub.2).sub.m -- with n=10-22, m=2-6; X is O, S, or NH; X.sub.1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX.sub.1 is HO-- or H.sub.2 N--, ##STR2## with [4] obtained as the free acid after saponification of the methyl ester.

History

Patent Number

US 6310058 B2

Other Application

09/578,973

Inventor

Marvin J. Miller Yanping Xu

Inventor from Local Institution

Marvin J. Miller

Assignee

University of Notre Dame Du Lac

Date Modified

2016-06-07

Language

  • English

Claims

16

Publisher

United States Patent and Trademark Office

Cooperative Patent Classification Codes

C07D 413/12 (20130101); C07D 403/12 (20130101)

Contributor

Marvin J. Miller

International Patent Classification Codes

C07D 403/12 (20060101); C07D 413/00 (20060101); C07D 403/00 (20060101); C07D 413/12 (20060101); A61K 031/55 (); C07D 413/12 ()

US Patent Classification Codes

514/212.08; 540/524;

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