Antimycobacterial agents

Patent

Description

Compounds represented by the formula [1] ##STR1## R.sub.1 is H or a substituent; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is siderophore group e.g. CH.sub.3 –(CH.sub.2).sub.n –C(O)–N(OH)–(CH.sub.2).sub.m – with n=10-22, m=2-6; X is O, S, or NH; X.sub.1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX.sub.1 is HO– or H.sub.2 N–, ##STR2## with [4] obtained as the free acid after saponification of the methyl ester.

Attributes

Attribute NameValues
Title
  • Antimycobacterial agents

Patent Number
  • US 6310058 B2

USPTO Link
Inventor
  • Marvin J. Miller

  • Yanping Xu

Inventor From Local Institution
  • Marvin J. Miller

Other Application
  • 09/578,973

Claims
  • 16

Classification (US Patent)
  • 514/212.08; 540/524;

Cooperative Patent Classification codes
  • C07D 413/12 (20130101); C07D 403/12 (20130101)

International Patent Classification codes
  • C07D 403/12 (20060101); C07D 413/00 (20060101); C07D 403/00 (20060101); C07D 413/12 (20060101); A61K 031/55 (); C07D 413/12 ()

Language
  • eng

Date Issued
  • 2001-10-30

Publisher
  • United States Patent and Trademark Office

Assignee
  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
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