Anti-bacterial siderophore-aminopenicillin conjugates

Patent

Description

An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-catecolate siderophores can be used with a variety of drugs as conjugates to target antibiotic-resistant Gram-negative bacteria.

Attributes

Attribute NameValues
Title
  • Anti-bacterial siderophore-aminopenicillin conjugates

Patent Number
  • US 9302012 B2

USPTO Link
Inventor
  • Marvin J. Miller

  • Cheng Ji

  • Patricia A. Miller

Inventor From Local Institution
  • Marvin J. Miller

  • Patricia A. Miller

Other Application
  • 13/865,801

Prior Publication Date
  • 2013-10-24

Prior Publication Number
  • US 20130281424 A1

Claims
  • 9

Cooperative Patent Classification codes
  • A61K 47/48023 (20130101); A61K 31/7056 (20130101); A61K 31/235 (20130101); A61K 47/48076 (20130101); A61K 31/133 (20130101); A61K 31/165 (20130101); A61K 31/40 (20130101); A61K 31/42 (20130101); A61K 31/405 (20130101); A61K 31/407 (20130101); A61K 31/4196 (20130101); A61K 31/427 (20130101); A61K 31/43 (20130101); A61K 31/439 (20130101); A61K 31/4409 (20130101); A61K 31/4439 (20130101); A61K 31/496 (20130101); A61K 31/545 (20130101); A61K 31/63 (20130101); A61K 31/635 (20130101); A61K 31/65 (20130101); A61K 31/702 (20130101); A61K 31/7024 (20130101); A61K 31/7036 (20130101); A61K 31/704 (20130101); A61K 31/7048 (20130101); A61K 31/167 (20130101)

International Patent Classification codes
  • A61K 31/167 (20060101); A61K 31/235 (20060101); A61K 47/48 (20060101)

Language
  • English

Date Issued
  • 2016-04-05

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame du Lac

Record Visibility Public
Content License
  • All rights reserved

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