US5750681.pdf (1.1 MB)
Bicyclic beta-lactams and process therefor
Bicyclic .beta.-lactams comprising a 5- or 6-membered lactone or lactam ring are obtained in a process comprising a base induced intramolecular cyclization of a 4-substututed .beta.-lactam having a leaving group in the 1-position. An intramolecular nucleophile transfer reaction is proposed as the operative mechanism and the bicyclic .beta.-lactams are obtained in the required stereochemical form for biological activity. The compounds provided are useful intermediates for the preparation of antibiotics and .beta.-lactamase inhibitors.
History
Patent Number
US 5750681 B2Other Application
08/491,821Inventor
Min Teng Marvin J. MillerInventor from Local Institution
Marvin J. MillerAssignee
University of Notre Dame Du LacDate Modified
2016-06-07Language
- English
Claims
7Publisher
United States Patent and Trademark OfficeCooperative Patent Classification Codes
C07D 471/04 (20130101); C07D 491/04 (20130101); C07D 487/04 (20130101)Contributor
Marvin J. MillerInternational Patent Classification Codes
C07D 487/00 (20060101); C07D 471/00 (20060101); C07D 471/04 (20060101); C07D 487/04 (20060101); C07D 491/00 (20060101); C07D 491/04 (20060101); C07D 207/00 ()US Patent Classification Codes
540/203;Usage metrics
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