Bicyclic beta-lactams and process therefor

Patent
Thumbnail

Description

Bicyclic .beta.-lactams comprising a 5- or 6-membered lactone or lactam ring are obtained in a process comprising a base induced intramolecular cyclization of a 4-substututed .beta.-lactam having a leaving group in the 1-position. An intramolecular nucleophile transfer reaction is proposed as the operative mechanism and the bicyclic .beta.-lactams are obtained in the required stereochemical form for biological activity. The compounds provided are useful intermediates for the preparation of antibiotics and .beta.-lactamase inhibitors.

Attributes
Attribute NameValues
Title

  • Bicyclic beta-lactams and process therefor

Patent Number

  • US 5750681 B2

USPTO Link
Inventor

  • Min Teng

  • Marvin J. Miller

Inventor From Local Institution

  • Marvin J. Miller

Other Application

  • 08/491,821

Claims

  • 7

Classification (US Patent)

  • 540/203;

Cooperative Patent Classification codes

  • C07D 471/04 (20130101); C07D 491/04 (20130101); C07D 487/04 (20130101)

International Patent Classification codes

  • C07D 487/00 (20060101); C07D 471/00 (20060101); C07D 471/04 (20060101); C07D 487/04 (20060101); C07D 491/00 (20060101); C07D 491/04 (20060101); C07D 207/00 ()

Language

  • eng

Date Issued

  • 1998-05-12

Publisher

  • United States Patent and Trademark Office

Assignee

  • University of Notre Dame Du Lac

Record Visibility and Access Public
Content License
Departments and Units
Member of

Collections
Collections Featuring this Patent
Notre Dame Patents

Files

Please Note: You may encounter a delay before a download begins. Large or infrequently accessed files can take several minutes to retrieve from our archival storage system.
Thumbnail File Name Description Size Type Access Actions
Thumbnail US5750681.pdf 1.1 MB application/pdf Public
1 to 1 of 1