Bicyclic beta-lactams and process therefor

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Description

Bicyclic .beta.-lactams comprising a 5- or 6-membered lactone or lactam ring are obtained in a process comprising a base induced intramolecular cyclization of a 4-substututed .beta.-lactam having a leaving group in the 1-position. An intramolecular nucleophile transfer reaction is proposed as the operative mechanism and the bicyclic .beta.-lactams are obtained in the required stereochemical form for biological activity. The compounds provided are useful intermediates for the preparation of antibiotics and .beta.-lactamase inhibitors.

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Attribute NameValues
Title

  • Bicyclic beta-lactams and process therefor

Patent Number

  • US 5750681 B2

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Inventor

  • Min Teng

  • Marvin J. Miller

Inventor From Local Institution

  • Marvin J. Miller

Other Application

  • 08/491,821

Claims

  • 7

Classification (US Patent)

  • 540/203;

Cooperative Patent Classification codes

  • C07D 471/04 (20130101); C07D 491/04 (20130101); C07D 487/04 (20130101)

International Patent Classification codes

  • C07D 487/00 (20060101); C07D 471/00 (20060101); C07D 471/04 (20060101); C07D 487/04 (20060101); C07D 491/00 (20060101); C07D 491/04 (20060101); C07D 207/00 ()

Language

  • eng

Date Issued

  • 1998-05-12

Publisher

  • United States Patent and Trademark Office

Assignee

  • University of Notre Dame Du Lac

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