Roles of Chronic Alcohol Feeding and the ID2 Gene in the Regulation of Circadian and Metabolic Function

Doctoral Dissertation
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Abstract

Chronic alcohol consumption contributes to fatty liver disease. My studies revealed that hepatic circadian clock is disturbed in the alcohol-induced hepatic steatosis, and effects of chronic alcohol administration upon the clock itself may contribute to steatosis. My studies also found that chronic alcohol consumption and liquid diet can differentially modulate the daily rhythmicity of locomotor and feeding behaviors; aspects that might contribute to disturbances in the circadian timing system and development of hepatic steatosis.

Inhibitor of DNA binding 2 (ID2) is a helix-loop-helix transcriptional repressor. My studies have demonstrated that Id2 null mice have sex-specific enhancement of insulin sensitivity and elevated glucose uptake in skeletal muscle and brown adipose tissue. Furthermore, I extend my studies on the characterization of the Id2 null mouse metabolic phenotype under energy-rich diet challenge in sex-specific context. These data provides insights into the impact of Id2 deficiency on metabolic homeostasis of mice in sexspecific manner.

Attributes

Attribute NameValues
URN
  • etd-04152015-093323

Author Peng Zhou
Advisor Giles E Duffield
Contributor John Duman, Committee Member
Contributor Lei Li, Committee Member
Contributor Zainulabeuddin.Syed, Committee Member
Contributor Giles E Duffield, Committee Chair
Degree Level Doctoral Dissertation
Degree Discipline Biological Sciences
Degree Name PhD
Defense Date
  • 2015-04-01

Submission Date 2015-04-15
Country
  • United States of America

Subject
  • alcohol

  • circadian

  • id2

Publisher
  • University of Notre Dame

Language
  • English

Record Visibility Public
Content License
  • All rights reserved

Departments and Units

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