Synthesis and use of croconaine compounds

Patent

Description

The present disclosure provides compositions and methods for the synthesis and use of croconaine compounds. The disclosed compounds are easily prepared from croconic acid. A halothiophene is reacted with an alkanolamine, the resulting aminothiophene is modified by appending a desired functional group to the hydroxyl group, and the modified aminothiophene is reacted with croconic acid to form the final compound. Applications of such croconaine compounds include photothermal imaging, photothermal therapy, light-activated drug release, and tissue welding.

Attributes

Attribute NameValues
Title
  • Synthesis and use of croconaine compounds

Patent Number
  • US 9353092 B2

USPTO Link
Inventor
  • Bradley D. Smith

Inventor From Local Institution
  • Bradley D. Smith

Other Application
  • 14/311,267

Prior Publication Date
  • 2015-01-01

Prior Publication Number
  • US 20150005501 A1

Claims
  • 20

International Patent Classification codes
  • C07D 409/14 (20060101); C07D 409/08 (20060101)

Language
  • English

Date Issued
  • 2016-05-31

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame du Lac

Record Visibility and Access Public
Content License
  • All rights reserved

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