Method of producing extracellular products from aerobic microorganisms

Disclosed is a method of producing an extracellular product from an aerobic microorganism. The microorganism is grown in an aqueous medium on one side of an oxygen-permeable surface while the opposite side of the surface is contacted with oxygen. The extracellular product is then harvested from the aqueous medium. The method is particularly useful in producing lignin peroxidase from the white rot fungus Phanerochaete chrysosporium.