Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof

Patent

Description

Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer.

Attributes

Attribute NameValues
Title
  • Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof

Patent Number
  • US 8,778,362 B2

USPTO Link
Inventor
  • Mark A. Suckow

  • Michael C. Hiles

Inventor From Local Institution
  • Mark A. Suckow

Other Application
  • 12/880,936

Prior Publication Date
  • 2012-03-15

Prior Publication Number
  • US 20120064163 A1

Claims
  • 16

Classification (US Patent)
  • 424/277.1; 424/423; 424/443; 424/484; 424/489

Cooperative Patent Classification codes
  • A61K 35/13 (20130101); A61K 35/22 (20130101); A61L 27/3633 (20130101); A61L 27/54 (20130101); C12N 5/0693 (20130101); A61L 2300/416 (20130101)

International Patent Classification codes
  • A61K 9/00 (20060101); A61K 9/70 (20060101); A61K 9/14 (20060101)

Language
  • English

Date Issued
  • 2014-07-15

Publisher
  • U.S. Patent and Trademark Office

Assignee
  • University of Notre Dame du Lac

  • Cook Biotech (West Lafayette, IN)

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